In the realm of organic synthesis, the availability of versatile and reactive building blocks is paramount for chemists pushing the boundaries of molecular design. 2-Bromo-3,4-difluoronitrobenzene (CAS No: 350699-92-2) is one such compound that offers significant synthetic potential. Its unique combination of halogen and nitro functionalities makes it a valuable intermediate for a wide array of chemical transformations, crucial for research and industrial applications. For organic chemists and purchasing managers, understanding its reactivity and how to source it efficiently is key to unlocking innovative synthesis pathways.

Understanding the Reactivity of 2-Bromo-3,4-difluoronitrobenzene

This chemical, often appearing as a light yellow liquid with a high purity of ≥98.0%, is characterized by its electron-deficient aromatic ring, primarily due to the presence of the nitro group and fluorine atoms. This electron deficiency activates the ring towards nucleophilic attack. The bromine atom provides a handle for cross-coupling reactions, such as Suzuki, Stille, or Heck couplings, allowing for the introduction of carbon-carbon bonds. The fluorine atoms can also influence reactivity and are often retained in the final product to impart specific properties like increased lipophilicity or metabolic stability, which are desirable in pharmaceuticals and agrochemicals. Its density is approximately 1.89 g/cm³, and it boils at 226.7°C at 760 mmHg, indicating reasonable stability under typical reaction conditions.

Key Synthetic Applications

The versatility of 2-Bromo-3,4-difluoronitrobenzene makes it a sought-after intermediate for:

  • Cross-Coupling Reactions: The aryl bromide moiety readily participates in palladium-catalyzed cross-coupling reactions, enabling the synthesis of complex biaryls and other substituted aromatic systems.
  • Nucleophilic Aromatic Substitution (SNAr): The activated aromatic ring can undergo SNAr reactions, where the nitro group or halogens can be displaced by nucleophiles, introducing new functional groups.
  • Reduction of Nitro Group: The nitro group can be reduced to an amine, providing a versatile intermediate for further derivatization, such as amide formation or diazotization.
  • Building Block for Specialty Chemicals: It serves as a fundamental component in the synthesis of advanced materials, dyes, and biologically active molecules used in pharmaceuticals and agrochemicals.

When you aim to buy this compound for your synthesis projects, selecting a supplier that guarantees high purity and consistent quality is essential. Sourcing from a reputable manufacturer ensures that the reactivity and performance of the material meet your expectations.

The Manufacturer's Edge: Quality Assurance and Supply Chain

As a leading manufacturer of fine chemicals, NINGBO INNO PHARMCHEM CO.,LTD. understands the critical role of reliable intermediates. We are committed to producing 2-Bromo-3,4-difluoronitrobenzene with exceptional purity (≥98.0%) and ensuring a stable supply chain. Our advanced manufacturing processes and rigorous quality control measures guarantee that chemists receive materials they can trust for reproducible synthetic outcomes. We are a dependable supplier in China, dedicated to supporting your research and development endeavors.

For researchers and procurement specialists, buying directly from a manufacturer offers several advantages, including competitive pricing and technical support. Our team is well-versed in the chemical industry and can provide the necessary documentation and assistance to facilitate your purchasing decisions. We actively invest in R&D to stay at the forefront of chemical synthesis, offering solutions that meet the evolving demands of the scientific community.

Strategic Sourcing Tips:

  • Prioritize Purity: Ensure the purity level meets the stringent requirements of your specific synthetic route.
  • Assess Supplier Expertise: Choose manufacturers with proven experience in producing high-quality intermediates.
  • Compare Pricing and Availability: Request quotes for your required quantities to secure the best value and ensure timely delivery.
  • Leverage Manufacturer Support: Take advantage of any technical assistance or custom synthesis services offered.

By strategically sourcing 2-Bromo-3,4-difluoronitrobenzene from a trusted manufacturer, organic chemists can confidently explore its extensive synthetic potential, accelerating discovery and innovation. If you are looking for a reliable supplier for this valuable chemical intermediate, we invite you to contact us to discuss your needs and explore our comprehensive offerings.