Omoconazole Nitrate (CAS 83621-06-1) is a synthetic imidazole derivative that has carved a significant niche in pharmaceutical applications, primarily for its antifungal properties. For researchers, chemists, and product developers, a deep understanding of its chemical synthesis and inherent properties is crucial for its effective utilization and for driving innovation. This article provides a technical overview, suitable for R&D professionals looking to delve into the chemical aspects of this important compound.

The chemical name for Omoconazole Nitrate is often described as 1-[(Z)-2-[2-(4-Chlorophenoxy)ethoxy]-2-(2,4-dichlorophenyl)-1-methylvinyl]-1H-imidazole, nitric acid. Its molecular formula is C20H17Cl3N2O2 · HNO3, giving it a molecular weight of approximately 486.73 g/mol. The presence of multiple chlorine atoms and the imidazole ring are key structural features that contribute to its biological activity. The synthesis typically involves a multi-step process, building the complex molecular structure from simpler precursors. While specific patented synthesis routes may vary, they generally aim to assemble the core imidazole moiety and the substituted phenyl-ether side chain.

The typical appearance of Omoconazole Nitrate as a white powder is indicative of its crystalline nature. This solid form is advantageous for handling, storage, and formulation into topical preparations. Key physical and chemical properties that are of interest to chemists include its melting point, solubility characteristics, and stability under various conditions. Its solubility in common organic solvents and its limited solubility in water are important factors influencing formulation design and stability studies. Information regarding its stability, particularly concerning degradation pathways and shelf-life, is vital for pharmaceutical development.

The mechanism of action of Omoconazole Nitrate, as previously mentioned, is the inhibition of fungal ergosterol biosynthesis. This biochemical pathway is essential for maintaining the structural integrity and fluidity of fungal cell membranes. By interfering with this pathway, Omoconazole Nitrate disrupts membrane function, leading to leakage of cellular contents and ultimately cell death. The specificity of this action against fungal enzymes, compared to mammalian sterol synthesis, contributes to its therapeutic index.

For chemical engineers and process chemists, optimizing the synthesis of Omoconazole Nitrate involves considering factors such as reaction yields, by-product formation, purification efficiency, and scalability. The development of cost-effective and environmentally friendly synthesis routes is an ongoing objective in the fine chemical industry. Ensuring the consistent production of high-purity Omoconazole Nitrate requires rigorous process control and analytical testing throughout the manufacturing cycle.

As a supplier of this critical intermediate, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing products that meet the exacting standards of the pharmaceutical industry. Understanding the chemical synthesis and properties of Omoconazole Nitrate allows us to better serve our R&D clients, providing them with reliable materials that facilitate their research and development efforts. Whether you are looking to buy Omoconazole Nitrate for established formulations or exploring new applications, our technical expertise and commitment to quality are at your disposal.