The art and science of chemical synthesis are fundamental to progress across industries, from pharmaceuticals to advanced materials. At the heart of this field are versatile organic intermediates, molecules that serve as essential building blocks for creating more complex structures. One such compound, 5-Bromo-7-azaindole (CAS 183208-35-7), stands out for its unique reactivity and broad applications in synthetic chemistry. This article explores the critical role of 5-Bromo-7-azaindole in molecule building and guides professionals on how to efficiently procure it.

Understanding 5-Bromo-7-azaindole's Synthetic Utility

5-Bromo-7-azaindole is characterized by its azaindole core, a heterocyclic aromatic system composed of fused pyridine and pyrrole rings, with a bromine atom strategically placed at the 5-position. This specific arrangement imparts distinct chemical properties that are highly prized in synthesis:

  • Reactive Bromine Atom: The bromine substituent is a key functional group, making the compound an excellent substrate for a wide array of palladium-catalyzed cross-coupling reactions. These include Suzuki-Miyaura coupling (forming C-C bonds with boronic acids), Heck reaction (coupling with alkenes), and Sonogashira coupling (coupling with alkynes). These reactions are indispensable for introducing diverse carbon-based substituents onto the azaindole framework.
  • Azaindole Core Reactivity: The nitrogen atoms within the azaindole ring can participate in coordination chemistry or undergo N-alkylation/acylation, further expanding the synthetic possibilities.
  • Versatile Intermediate: Its structure makes it a crucial intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialized functional materials. Notably, it is recognized for its role as a ZCCHC12 inhibitor, highlighting its biological relevance.

Key Synthesis Pathways Utilizing 5-Bromo-7-azaindole

Chemists leverage 5-Bromo-7-azaindole in numerous synthetic strategies:

  • Construction of Complex Heterocycles: It serves as a scaffold to build more intricate fused or substituted heterocyclic systems, which are common structural motifs in drug molecules.
  • Introduction of Functional Groups: Through cross-coupling reactions, various functional groups can be appended to the azaindole ring, allowing for fine-tuning of molecular properties.
  • Development of Biologically Active Compounds: Its use in creating compounds that target specific biological pathways, like those involving ZCCHC12, makes it a valuable asset in medicinal chemistry research.

Sourcing 5-Bromo-7-azaindole: A Strategic Procurement Decision

When the need arises to buy 5-Bromo-7-azaindole, selecting a reliable manufacturer and supplier is critical for the success of your synthetic projects. As a dedicated producer of high-quality organic intermediates, we understand the importance of consistent purity and reactivity. Our commitment is to provide researchers and chemists with a dependable source for this essential compound. When you search for a “7-azaindole intermediate manufacturer” or a “CAS 183208-35-7 supplier,” consider our offerings for:

  • Guaranteed Purity: We offer 5-Bromo-7-azaindole typically at 99% purity, ensuring reliable performance in sensitive reactions.
  • Competitive Price: Leveraging our manufacturing expertise in China, we provide cost-effective solutions without compromising on quality.
  • Technical Documentation: Access to Certificates of Analysis and other relevant data to support your synthesis planning.

In conclusion, 5-Bromo-7-azaindole is a pivotal compound in modern chemical synthesis, enabling the construction of a vast array of complex molecules. Its reactivity and versatility make it an indispensable tool for chemists in pharmaceutical R&D, materials science, and beyond. By partnering with a trusted supplier, you can ensure efficient and successful molecule building, accelerating your research and development timelines.