In the realm of organic chemistry and material science, the availability of specialized building blocks is crucial for innovation. Fmoc-alpha-methylalanine (Fmoc-Aib-OH), identified by CAS 94744-50-0, is one such compound that finds significant application in various chemical synthesis endeavors. This article provides an overview of its chemical properties and outlines how researchers can effectively source this essential reagent from reliable providers.

Understanding the Chemistry of Fmoc-Aib-OH

Fmoc-Aib-OH is an Fmoc-protected amino acid derivative, specifically an alpha-methylated alanine. Its molecular formula is C19H19NO4, and it has a molecular weight of 325.36. Typically appearing as a white to off-white crystalline powder, it possesses a high purity level (≥98%), making it suitable for demanding synthetic applications. The Fmoc group is a base-labile protecting group, facilitating controlled deprotection during multi-step synthesis, particularly in peptide synthesis.

The presence of the alpha-methyl group on the alanine residue imparts unique conformational properties and steric bulk, which can influence the reactivity and structure of synthesized molecules. This makes Fmoc-Aib-OH a valuable tool for creating complex organic structures with specific functionalities.

Applications in Chemical Synthesis

  • Peptide Synthesis: This is perhaps the most prominent application. Fmoc-Aib-OH is extensively used in solid-phase peptide synthesis (SPPS) to incorporate alpha-methylated alanine residues. These residues can enhance peptide stability against enzymatic degradation and influence secondary structure formation, crucial for peptide-based therapeutics and research tools. Researchers often look to buy Fmoc-Aib-OH for these advanced synthesis needs.
  • Peptidomimetics: Fmoc-Aib-OH serves as a key building block in the synthesis of peptidomimetics – compounds that mimic the structure and function of peptides but possess improved pharmacological properties, such as oral bioavailability or resistance to metabolism.
  • Chiral Synthesis: As a chiral molecule, Fmoc-Aib-OH can be utilized in asymmetric synthesis, contributing to the creation of enantiomerically pure compounds.
  • Organic Synthesis: Beyond peptides, its reactive functional groups make it adaptable for various organic synthesis pathways, enabling the construction of complex molecules in areas like medicinal chemistry and materials science.

Sourcing Fmoc-Aib-OH: Finding a Reliable Manufacturer and Supplier

For researchers needing to buy Fmoc-Aib-OH, identifying a dependable supplier is critical. Key considerations include product purity, batch-to-batch consistency, competitive price, and timely delivery. Many researchers turn to Chinese chemical manufacturers for their supply of such specialized reagents, owing to their advanced production capabilities and cost-effectiveness.

When you purchase Fmoc-Aib-OH, it is important to partner with a manufacturer that provides a Certificate of Analysis (CoA) and adheres to strict quality control measures. We pride ourselves on being a trusted supplier of high-quality Fmoc-Aib-OH, offering competitive pricing and reliable service to the research community. We encourage you to inquire about our products and experience the difference that quality sourcing makes in your chemical synthesis projects.