The field of chemical synthesis is constantly evolving, with a growing emphasis on chiral molecules that offer specific biological activities and reaction selectivities. (S)-5-Hydroxymethyldihydrofuran-2-one (CAS 32780-06-6) is a prominent example of such a chiral building block, indispensable for many advanced synthetic projects. For chemists and procurement specialists, understanding where and how to buy this versatile compound is crucial for project success. This guide aims to provide insights into its applications and effective sourcing strategies.

Understanding the Compound: Properties and Versatility

(S)-5-Hydroxymethyldihydrofuran-2-one is a chiral lactone characterized by its specific (S)-configuration. This stereochemical precision is what makes it so valuable in enantioselective synthesis. Typically appearing as a colorless to pale yellow liquid, it exhibits good solubility in common organic solvents, facilitating its use in various reaction conditions.

Its structure features a reactive hydroxymethyl group and a lactone ring, making it amenable to a wide range of chemical transformations. These include:

  • Oxidation: The hydroxymethyl group can be oxidized to a carboxylic acid, extending synthetic possibilities.
  • Substitution: Nucleophilic substitutions can occur at the hydroxymethyl group, allowing for the introduction of diverse functionalities.
  • Ring Opening/Modification: The lactone ring can be opened or further functionalized to create new molecular scaffolds.

These reactive sites make it a key intermediate for synthesizing complex molecules used in pharmaceuticals, agrochemicals, and materials science.

Applications Driving Demand

The demand for (S)-5-Hydroxymethyldihydrofuran-2-one is significantly driven by its applications in cutting-edge research and development:

  • Pharmaceutical Industry: It serves as a chiral synthon for creating active pharmaceutical ingredients (APIs) and complex drug intermediates, such as those for antiviral and cholesterol-lowering medications. For instance, its role in synthesizing mevinic acid analogs is well-documented.
  • Organic Synthesis: Researchers utilize it for constructing natural products and preparing optically active ligands for catalysis.
  • Biochemical Research: Its potential biological activities, such as cytotoxic effects on cancer cell lines, are areas of ongoing investigation.

When professionals decide to buy (S)-5-Hydroxymethyldihydrofuran-2-one, they often prioritize purity, availability, and competitive pricing. For bulk purchases, understanding the price per kilogram from different suppliers in regions like China is a critical part of the procurement process.

Finding Reliable Suppliers and Manufacturers

Securing a consistent supply of high-quality (S)-5-Hydroxymethyldihydrofuran-2-one is essential for any research or manufacturing project. When sourcing this chemical, particularly from international markets, it’s vital to partner with reputable manufacturers and suppliers.

Key considerations for buyers include:

  • Purity and Assay: Ensure the product meets the required specifications, typically with an assay of ≥95%.
  • Supplier Reputation: Look for established companies with a proven track record in supplying fine chemicals.
  • Pricing and Value: Compare quotes from multiple suppliers to find the best balance of price and quality. Understanding the price trends for bulk quantities is important.
  • Technical Support and Documentation: Access to technical data sheets, certificates of analysis, and responsive customer service is highly beneficial.

Many Chinese manufacturers offer competitive pricing for (S)-5-Hydroxymethyldihydrofuran-2-one, making it an attractive option for global buyers. Focusing on suppliers who provide excellent quality control and reliable delivery ensures that your synthesis projects proceed without interruption.

In conclusion, (S)-5-Hydroxymethyldihydrofuran-2-one is a valuable chiral building block with diverse applications in chemical synthesis, particularly in the pharmaceutical sector. By carefully selecting a dependable manufacturer and supplier, researchers and procurement specialists can access this critical intermediate, paving the way for innovation and successful product development. Explore the market and find the best partner to meet your synthesis needs.