In the realm of organic chemistry, certain molecules serve as foundational building blocks, enabling the creation of a vast array of complex compounds. 2-Bromo-5-hydroxypyridine (CAS: 55717-45-8), also known as 6-Bromo-3-pyridinol, is one such versatile intermediate, valued for its reactivity and its presence in numerous synthetic pathways across pharmaceutical, agrochemical, and material science sectors.

Understanding the Structure and Reactivity

The chemical structure of 2-Bromo-5-hydroxypyridine is characterized by a pyridine ring substituted with a bromine atom at the 2-position and a hydroxyl group at the 5-position. This arrangement imbues the molecule with distinct reactivity:

  • Electrophilic Bromine Atom: The bromine atom is a good leaving group, making the pyridine ring susceptible to nucleophilic aromatic substitution or, more commonly, palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Heck, Sonogashira). These reactions are cornerstones for forming new carbon-carbon bonds and introducing complex moieties.
  • Nucleophilic Hydroxyl Group: The hydroxyl group can undergo various functionalization reactions, such as etherification, esterification, or O-alkylation. It also influences the electronic properties of the pyridine ring and can participate in hydrogen bonding.
  • Pyridine Ring System: The nitrogen atom in the pyridine ring can act as a Lewis base, coordinating with metals or participating in acid-base chemistry.

Key Synthetic Transformations and Applications

The versatility of 2-Bromo-5-hydroxypyridine allows chemists to employ it in a multitude of synthetic strategies:

  • Pharmaceutical Intermediates: It is a crucial precursor for many APIs, enabling the synthesis of compounds with potential therapeutic activities, such as those targeting neurological disorders or acting as kinase inhibitors. When researchers need to buy specific pyridine derivatives for drug discovery, this compound is often a starting point.
  • Agrochemicals: The pyridine scaffold is common in herbicides and insecticides. 2-Bromo-5-hydroxypyridine serves as a building block for creating novel agrochemical agents that enhance crop protection and yield.
  • Material Science: Derivatives of this compound can be incorporated into functional materials, such as organic light-emitting diodes (OLEDs) or polymers, due to their electronic properties and stability.
  • Ligand Synthesis: The pyridine moiety, combined with the potential for further functionalization, makes it useful in the synthesis of ligands for catalysis.

Sourcing High-Quality 2-Bromo-5-hydroxypyridine

For any chemist or procurement specialist looking to utilize 2-Bromo-5-hydroxypyridine in their synthesis, sourcing from a reliable manufacturer and supplier is critical. NINGBO INNO PHARMCHEM CO.,LTD. is a leading provider of this intermediate from China. We ensure high purity (≥97%) and consistent quality, backed by comprehensive analytical data. Whether you are looking to purchase research quantities or bulk materials, our commitment to quality and competitive pricing makes us an ideal choice.

By understanding the chemical versatility of 2-Bromo-5-hydroxypyridine and partnering with a trusted source like NINGBO INNO PHARMCHEM CO.,LTD., chemists can effectively leverage this compound to achieve their synthetic goals and drive innovation in their respective fields. Contact us today for a quote and discover how we can support your chemical needs.