2,6-Difluoropyridine (CAS 1513-65-1) is a heterocyclic organic compound that has garnered significant attention, primarily for its utility as a building block in the pharmaceutical industry. Understanding its synthesis, chemical properties, and market dynamics is crucial for procurement specialists, R&D scientists, and chemical manufacturers. This article provides a comprehensive overview, offering insights for those looking to buy 2,6-Difluoropyridine.

Synthesis Routes for 2,6-Difluoropyridine

Several methods can be employed for the synthesis of 2,6-Difluoropyridine. One common approach involves the halogen exchange reaction from 2,6-dichloropyridine using a fluorinating agent like tetramethylammonium fluoride (NMe4F). This reaction typically occurs in a polar aprotic solvent such as DMF at room temperature. The efficiency of such reactions is often monitored using techniques like GC-MS and NMR spectroscopy. The availability of robust synthesis methods ensures a consistent supply from reliable manufacturers.

Key Chemical and Physical Properties

2,6-Difluoropyridine is characterized by its colorless liquid appearance. Key properties include:

  • Molecular Formula: C5H3F2N
  • Molecular Weight: 115.08
  • Boiling Point: Approximately 124.5°C at 743 mmHg.
  • Density: Around 1.268 g/cm³ at 25°C.
  • Refractive Index: n20/D 1.437.
  • Flash Point: 93°F, indicating flammability.
  • Purity: Typically available at ≥99.0% purity.

These properties are essential for formulators and researchers to consider during application and handling. Safe storage in a tightly closed container in a cool, dry place is recommended.

Market Insights and Sourcing 2,6-Difluoropyridine

The global market for 2,6-Difluoropyridine is driven by the pharmaceutical sector's demand for advanced intermediates. As such, the price can fluctuate based on supply, demand, and raw material costs. When seeking to purchase 2,6-Difluoropyridine, it is advisable to work with established suppliers and manufacturers who can provide detailed technical documentation and ensure product consistency. Sourcing from regions like China, which hosts a significant number of fine chemical producers, can often lead to competitive pricing. Businesses looking for a reliable supplier should evaluate companies based on their production capacity, quality control measures, and customer service.

Understanding the chemical synthesis, properties, and market dynamics of 2,6-Difluoropyridine empowers buyers and researchers to make informed decisions. If your research or production requires this valuable intermediate, consider reaching out to reputable sources for quotes and samples to ensure you are obtaining the highest quality material for your specific applications.