For those involved in organic synthesis and chemical development, a thorough understanding of key intermediates is essential. 2,6-Dimethoxyaniline, identified by CAS number 2734-70-5, is a compound whose chemical properties make it a valuable asset in various synthetic routes. This article explores its synthesis, physical and chemical characteristics, and how these attributes are leveraged by R&D scientists and product formulators.

Synthesis Pathways for 2,6-Dimethoxyaniline

While specific proprietary synthesis methods vary among manufacturers, common routes to 2,6-Dimethoxyaniline (C8H11NO2) often involve the reduction of corresponding nitro compounds or the amination of appropriately substituted aromatic rings. For instance, the reduction of 2,6-dimethoxy-nitrobenzene is a frequently employed method. The choice of reducing agent, reaction conditions, and purification techniques are critical to achieving high yields and the desired purity, which is typically ≥98.0% for commercial applications. As a dedicated supplier, we focus on optimized synthesis processes to deliver consistent quality.

Key Physical and Chemical Properties

2,6-Dimethoxyaniline typically appears as an off-white to light yellow powder. Its molecular weight is approximately 153.178 g/mol. Key physical properties include a melting point range of 71-74°C and a boiling point of around 253.6°C at 760 mmHg. Its solubility profile generally shows good solubility in common organic solvents like ethanol and ether, with limited solubility in water, a characteristic influenced by the hydrophobic methoxy groups.

Chemically, the presence of the amino group makes it a base, capable of forming salts with acids. The electron-donating nature of the methoxy groups activates the aromatic ring towards electrophilic substitution, primarily at the para position. This reactivity is fundamental to its utility as an intermediate. For instance, it can undergo acetylation, alkylation, and is a common participant in coupling reactions, which are vital for building more complex molecular structures.

Applications Driven by Properties

The combination of its amine functionality and the activating methoxy groups makes 2,6-Dimethoxyaniline invaluable for synthesizing a range of compounds. Its role as a pharmaceutical intermediate is significant, contributing to the structure of various drug molecules. In the fine chemical industry, it is used to construct specialty organic compounds. Researchers looking to buy this intermediate will find its predictable reactivity and solid form convenient for laboratory work. Understanding these properties allows chemists to strategically incorporate it into their synthesis plans.

As a manufacturer and supplier, we ensure that our 2,6-Dimethoxyaniline meets the precise specifications required for these demanding chemical applications. We encourage prospective buyers to reach out for detailed technical data and quotes to explore how this versatile compound can benefit their projects.