For chemists and R&D professionals, understanding the synthesis and reactivity of a chemical intermediate is fundamental to its effective utilization. 2-Aminobenzophenone (CAS 2835-77-0) is a compound whose chemical properties make it a valuable asset in various synthetic endeavors, particularly within the pharmaceutical and agrochemical sectors. As a knowledgeable manufacturer, we offer insights into the chemistry that underpins this important molecule.

Synthesis Routes of 2-Aminobenzophenone

Several synthetic pathways can lead to the formation of 2-Aminobenzophenone. A common and industrially relevant method involves the Friedel-Crafts acylation of aniline derivatives or related compounds. One established route includes the reaction between 2-aminobenzonitrile and benzene under specific catalytic conditions. Another approach might involve the condensation reactions of aniline with benzoyl chloride or its derivatives, followed by necessary purification steps to achieve the required high purity (typically ≥99%). The specific choice of synthesis route by a manufacturer often depends on raw material availability, cost-effectiveness, and environmental considerations.

The resulting product, a yellow-gold fine crystalline powder, is then characterized by its molecular formula C13H11NO and CAS number 2835-77-0.

Key Reactivity and Applications Explained

The bifunctional nature of 2-Aminobenzophenone, possessing both an amine (-NH2) group and a ketone (C=O) group, dictates its rich reactivity:

  • Reactions of the Amine Group: The primary amine group can undergo typical reactions such as alkylation, acylation, and diazotization. These transformations are crucial for building more complex molecular structures. For instance, diazotization followed by coupling reactions can be used in dye synthesis.
  • Reactions of the Ketone Group: The carbonyl group is susceptible to nucleophilic addition, reduction, and condensation reactions. It can also participate in intramolecular cyclization reactions when appropriately functionalized precursors are used.
  • Formation of Heterocyclic Compounds: Perhaps its most significant application stems from its ability to serve as a precursor for various heterocyclic systems. For example, it is a key intermediate in the synthesis of quinoline derivatives, which are prevalent in pharmaceuticals and agrochemicals.

These reactive sites are precisely what make 2-Aminobenzophenone indispensable in the synthesis of pharmaceuticals like antihistamines, hypnotics, and antidepressants, as well as in the formulation of pesticides. Researchers often seek this compound when exploring new synthetic pathways to novel APIs or agrochemical active ingredients.

Quality and Consistency from Your Supplier

When you look to buy 2-Aminobenzophenone, understanding its chemical properties allows you to better appreciate the importance of sourcing from a quality-assured supplier. The presence of impurities or incorrect isomeric forms can significantly hinder downstream reactions or lead to off-specification end products. Reputable manufacturers ensure that their production processes yield a product with consistent chemical integrity.

Conclusion

The chemistry of 2-Aminobenzophenone is central to its utility as a versatile intermediate. Its synthesis routes are well-established, and its reactivity allows for the creation of a wide array of complex organic molecules. For those engaged in pharmaceutical development or agrochemical innovation, partnering with a manufacturer that understands and delivers on the chemical precision of 2-Aminobenzophenone is a critical step towards success.