Exploring the Chemistry of 2-Bromo-5-fluorobenzotrifluoride (CAS 40161-55-5)
The chemical industry continuously seeks novel compounds and efficient synthetic routes to drive innovation. Within this context, 2-Bromo-5-fluorobenzotrifluoride (CAS: 40161-55-5) has emerged as a compound of significant interest due to its versatile chemical structure and broad applicability. This halogenated aromatic compound, featuring a trifluoromethyl group and both bromine and fluorine substituents, offers unique reactivity profiles that are highly valuable in organic synthesis. NINGBO INNO PHARMCHEM CO., LTD. is committed to providing high-quality intermediates like this to support research and development efforts globally.
The molecular architecture of 2-Bromo-5-fluorobenzotrifluoride is key to its utility. The electron-withdrawing trifluoromethyl group, along with the electronegative fluorine atom, significantly influences the electron density distribution on the aromatic ring. The bromine atom, a good leaving group, readily participates in a variety of transformations, including palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira), nucleophilic aromatic substitution, and organometallic reagent formation. This inherent reactivity makes it an excellent starting material for building complex molecular frameworks.
Its most prominent role is as a pharmaceutical intermediate. The incorporation of fluorine atoms and trifluoromethyl groups into drug molecules is a well-established strategy for enhancing their lipophilicity, metabolic stability, and binding affinity to target proteins. Consequently, 2-Bromo-5-fluorobenzotrifluoride is extensively used in the synthesis of APIs for various therapeutic areas. Researchers leverage its structure to design and synthesize drug candidates with improved pharmacological profiles.
In addition to pharmaceuticals, the compound also finds application in the development of advanced agrochemicals. Fluorine incorporation can improve the efficacy, stability, and selectivity of pesticides, herbicides, and fungicides, leading to more effective and environmentally sustainable crop protection solutions.
The precise synthesis of 2-Bromo-5-fluorobenzotrifluoride is a critical aspect of its commercial availability. Manufacturers employ sophisticated multi-step synthesis protocols, ensuring high purity and consistent quality, which are essential for its use in sensitive chemical processes.
Understanding the specific CAS 40161-55-5 chemical properties is fundamental for its effective handling and utilization. As a colorless liquid, its physical characteristics, such as density and refractive index, are important parameters for chemists to consider during reaction planning and scale-up.
As a representative of vital organic synthesis intermediates, 2-Bromo-5-fluorobenzotrifluoride enables innovation across a spectrum of chemical disciplines. Its availability and versatility empower scientists to create novel materials, design advanced agrochemicals, and develop life-saving pharmaceuticals.
In conclusion, 2-Bromo-5-fluorobenzotrifluoride is a testament to the power of molecular design in chemistry. Its multifaceted role as a building block in organic synthesis, particularly in the pharmaceutical and agrochemical sectors, underscores its importance in driving scientific progress and technological advancement. Companies like NINGBO INNO PHARMCHEM CO., LTD. are instrumental in providing these critical materials, fueling the engine of chemical innovation.
The molecular architecture of 2-Bromo-5-fluorobenzotrifluoride is key to its utility. The electron-withdrawing trifluoromethyl group, along with the electronegative fluorine atom, significantly influences the electron density distribution on the aromatic ring. The bromine atom, a good leaving group, readily participates in a variety of transformations, including palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira), nucleophilic aromatic substitution, and organometallic reagent formation. This inherent reactivity makes it an excellent starting material for building complex molecular frameworks.
Its most prominent role is as a pharmaceutical intermediate. The incorporation of fluorine atoms and trifluoromethyl groups into drug molecules is a well-established strategy for enhancing their lipophilicity, metabolic stability, and binding affinity to target proteins. Consequently, 2-Bromo-5-fluorobenzotrifluoride is extensively used in the synthesis of APIs for various therapeutic areas. Researchers leverage its structure to design and synthesize drug candidates with improved pharmacological profiles.
In addition to pharmaceuticals, the compound also finds application in the development of advanced agrochemicals. Fluorine incorporation can improve the efficacy, stability, and selectivity of pesticides, herbicides, and fungicides, leading to more effective and environmentally sustainable crop protection solutions.
The precise synthesis of 2-Bromo-5-fluorobenzotrifluoride is a critical aspect of its commercial availability. Manufacturers employ sophisticated multi-step synthesis protocols, ensuring high purity and consistent quality, which are essential for its use in sensitive chemical processes.
Understanding the specific CAS 40161-55-5 chemical properties is fundamental for its effective handling and utilization. As a colorless liquid, its physical characteristics, such as density and refractive index, are important parameters for chemists to consider during reaction planning and scale-up.
As a representative of vital organic synthesis intermediates, 2-Bromo-5-fluorobenzotrifluoride enables innovation across a spectrum of chemical disciplines. Its availability and versatility empower scientists to create novel materials, design advanced agrochemicals, and develop life-saving pharmaceuticals.
In conclusion, 2-Bromo-5-fluorobenzotrifluoride is a testament to the power of molecular design in chemistry. Its multifaceted role as a building block in organic synthesis, particularly in the pharmaceutical and agrochemical sectors, underscores its importance in driving scientific progress and technological advancement. Companies like NINGBO INNO PHARMCHEM CO., LTD. are instrumental in providing these critical materials, fueling the engine of chemical innovation.
Perspectives & Insights
Chem Catalyst Pro
“Its availability and versatility empower scientists to create novel materials, design advanced agrochemicals, and develop life-saving pharmaceuticals.”
Agile Thinker 7
“In conclusion, 2-Bromo-5-fluorobenzotrifluoride is a testament to the power of molecular design in chemistry.”
Logic Spark 24
“Its multifaceted role as a building block in organic synthesis, particularly in the pharmaceutical and agrochemical sectors, underscores its importance in driving scientific progress and technological advancement.”