For procurement managers and research scientists in the chemical and pharmaceutical industries, understanding the fundamental properties of key intermediates is vital for successful development and manufacturing. 2-Picolinic Acid (CAS 98-98-6), a compound with a pyridine ring and a carboxylic acid group at the second position, presents a fascinating case study in chemical behavior, including its solubility, crystallization patterns, and synthesis pathways. As a premier manufacturer and supplier, we provide insights into these critical aspects.

Solubility and Solvent Interactions

The solubility of 2-Picolinic Acid varies significantly depending on the solvent. Research indicates that it is highly soluble in water, considerably less so in ethanol, and even less in acetonitrile. This differential solubility is influenced by the solvent's ability to form hydrogen bonds with the 2-Picolinic Acid molecule. Specifically, solvents capable of strong hydrogen bonding, like water, tend to solvate the molecule more effectively. This understanding is crucial for process chemists when designing crystallization protocols or reaction media. When you consider '2-picolinic acid price' or look to 'buy 2-picolinic acid', the context of its solubility can inform your choice of processing solvents.

Polymorphism and Solid-State Structure

2-Picolinic Acid exhibits polymorphism, meaning it can exist in different crystalline forms. Studies have identified at least two polymorphic forms, with no evidence of hydrates or solvates being reported. The specific crystalline form can influence physical properties such as dissolution rate, stability, and handling characteristics. For industries like pharmaceuticals, where solid-state properties are critical for drug bioavailability and formulation stability, understanding and controlling polymorphism is essential. Researchers often investigate crystallization conditions to isolate the desired polymorph. This focus on solid-state chemistry highlights why sourcing from a manufacturer with robust quality control is important.

Synthesis Pathways for 2-Picolinic Acid

The synthesis of 2-Picolinic Acid can be achieved through several methods. A common industrial route involves the hydrolysis of 2-cyanopyridine using sodium hydroxide, followed by acidification. This process typically yields good results, with high purity achievable through appropriate purification techniques such as crystallization from water or benzene. Another method described involves the oxidation of 2-(hydroxymethyl)pyridine. For businesses looking to 'buy 2-picolinic acid' in bulk, understanding these synthesis and purification methods underscores the importance of choosing a supplier with well-established manufacturing processes to ensure consistent quality and reliable output.

Partnering with a Trusted Manufacturer

As a leading supplier of 2-Picolinic Acid, we are committed to providing material that meets the highest standards of purity and consistency. Whether your application is in pharmaceuticals, health supplements, or advanced organic synthesis, our detailed understanding of its chemical properties ensures you receive a product that will perform reliably. If you are seeking a reliable source for 2-picolinic acid in China, contact us for competitive pricing and dedicated service.