In the intricate world of chemical synthesis, certain compounds stand out for their versatility and indispensable role in creating advanced materials and therapeutics. 3-Chloro-4-fluorophenol (CAS: 2613-23-2) is one such compound, a halogenated phenol that serves as a critical intermediate in numerous industrial processes. Understanding its chemical properties, synthesis methods, and diverse applications is essential for chemists and product developers seeking to leverage its potential. If you are looking to buy 3-Chloro-4-fluorophenol for your next project, this overview will highlight its significance.

Chemical Profile of 3-Chloro-4-fluorophenol

3-Chloro-4-fluorophenol, with the molecular formula C6H4ClFO and a molecular weight of 146.55 g/mol, is characterized by a phenol ring substituted with a chlorine atom at the 3-position and a fluorine atom at the 4-position. Its physical properties include a melting point typically between 38-40°C and a boiling point of approximately 225°C at standard atmospheric pressure. The compound typically appears as a yellow to brown crystalline powder, with an assay of ≥98.0%, indicating a high level of purity suitable for demanding applications. The presence of both chlorine and fluorine atoms imparts unique reactivity, making it a valuable reactant in electrophilic aromatic substitution and nucleophilic aromatic substitution reactions.

Synthesis Pathways and Sourcing Considerations

The synthesis of 3-Chloro-4-fluorophenol often involves multi-step chemical processes starting from readily available precursors. While specific industrial routes can vary, common strategies might involve selective halogenation and subsequent functional group transformations. For manufacturers, optimizing these synthesis routes is key to achieving high yields and purity while managing production costs. For buyers, sourcing from a reliable chemical supplier or manufacturer, especially one based in China, can offer competitive pricing and consistent availability for this intermediate. When considering a purchase, always request a detailed specification sheet and ensure the supplier can provide batch-consistent quality.

Diverse Applications Across Industries

The utility of 3-Chloro-4-fluorophenol spans several key industries:

  • Pharmaceutical Research: It is widely used as an intermediate in the synthesis of various pharmaceuticals. The fluorine atom, in particular, can enhance the metabolic stability and binding affinity of drug candidates, making it a sought-after building block in medicinal chemistry. Researchers often seek this compound for the development of novel therapeutic agents.
  • Agrochemicals: In the agricultural sector, 3-Chloro-4-fluorophenol serves as a precursor for herbicides, pesticides, and plant growth regulators. Its incorporation into agrochemical formulations can lead to more effective and targeted crop protection solutions.
  • Material Science: Fluorinated aromatic compounds are increasingly explored for their unique properties in material science, such as thermal stability and chemical resistance. 3-Chloro-4-fluorophenol can be an intermediate in the development of specialty polymers and functional materials.
  • Fine Chemical Synthesis: Beyond pharmaceuticals and agrochemicals, it is a general intermediate for a broad range of fine chemicals, enabling the synthesis of dyes, pigments, and other specialty organic molecules.

Conclusion: A Cornerstone Intermediate

3-Chloro-4-fluorophenol is more than just a chemical; it's an enabler of innovation across multiple scientific and industrial domains. Its well-defined chemical properties and the ability to participate in complex synthetic transformations make it indispensable. Whether you are a research scientist developing the next breakthrough drug or a production manager optimizing agrochemical formulations, understanding and sourcing high-quality 3-Chloro-4-fluorophenol from a reputable supplier is a crucial step. For those looking to buy, exploring options from established manufacturers will ensure you receive a product that meets stringent industry requirements and drives your projects forward.