For chemists and researchers engaged in organic synthesis, understanding the intrinsic properties and reactivity of chemical intermediates is fundamental. 3-Chloropropyl Chloroformate, identified by CAS number 628-11-5, is a compound whose chemical characteristics dictate its wide utility. Its unique structure as a bifunctional molecule makes it a highly sought-after building block in both academic research and industrial applications, particularly within the pharmaceutical and agrochemical sectors. As a leading manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. provides insights into this important compound.

Key Chemical Properties:

Molecular Formula and Weight: The chemical formula for 3-Chloropropyl Chloroformate is C4H6Cl2O2, with a molecular weight of approximately 156.99 g/mol. This provides a foundational understanding of its composition and stoichiometry in reactions.

Physical Appearance: Typically, this compound presents as a colorless to pale yellow liquid. Its physical state at room temperature is liquid, consistent with its boiling point.

Boiling Point and Density: With a reported boiling point ranging from 177.8°C to 189°C (at atmospheric pressure), it indicates a relatively stable compound that can withstand moderate heating during synthesis. Its density is approximately 1.302 g/mL at 25°C, suggesting it is denser than water.

Reactivity: A Bifunctional Intermediate:

The true value of 3-Chloropropyl Chloroformate lies in its bifunctional nature:

1. Chloroformate Group (-O-CO-Cl): This highly reactive acyl chloride ester moiety readily undergoes nucleophilic substitution. It reacts with alcohols to form carbonates, with amines to form carbamates, and can also participate in Friedel-Crafts acylation reactions. This makes it an excellent agent for introducing carbonyl groups and protecting hydroxyl or amine functionalities.

2. Chloropropyl Group (-CH2CH2CH2Cl): The terminal alkyl chloride group provides another reactive site for nucleophilic substitution or alkylation reactions. This allows for the extension of carbon chains or the introduction of specific substituents onto other molecules.

Applications Driven by Reactivity:

The combined reactivity of these two functional groups makes 3-Chloropropyl Chloroformate indispensable in:

  • Pharmaceutical Synthesis: For building complex drug scaffolds, introducing protective groups, and creating carbonate or carbamate linkages common in many APIs.
  • Agrochemicals: In the synthesis of pesticides, herbicides, and fungicides, where specific functional groups impart desired biological activity.
  • Organic Building Blocks: As a versatile starting material for a wide range of organic transformations and the creation of novel compounds.

As a reliable manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. ensures that our 3-Chloropropyl Chloroformate is produced to high standards, meeting the precise chemical requirements for your synthesis projects. If you are looking to buy this essential intermediate, our expert team is ready to assist you with quotes and technical details.