Understanding the fundamental chemistry of key intermediates is crucial for R&D professionals. 4-Amino-3-bromobenzonitrile (CAS: 50397-74-5) is a prime example of an organic compound whose specific molecular architecture dictates its broad utility. This article explores its key physical and chemical properties, typical synthesis pathways, and structural characteristics, providing valuable insights for chemists and procurement specialists seeking reliable sources.

Physically, 4-Amino-3-bromobenzonitrile typically presents as a light yellow to brown powder. Its melting point range is generally cited between 106-110 °C, indicating a stable solid form under ambient conditions. With a molecular formula of C7H5BrN2 and a molecular weight of 197.032 g/mol, its precise composition is well-defined. The density is around 1.7 g/cm³, and it possesses a relatively high boiling point of approximately 300.3 °C at 760 mmHg, suggesting low volatility. These properties are important considerations for handling, storage, and reaction design.

The molecular structure of 4-Amino-3-bromobenzonitrile features a benzene ring substituted with an amino group (-NH2) at position 4, a bromine atom (-Br) at position 3, and a nitrile group (-CN) at position 1. This specific arrangement of functional groups is what confers its reactivity and versatility as a synthetic intermediate. The electron-donating amino group and the electron-withdrawing nitrile group influence the reactivity of the aromatic ring, while the bromine atom serves as an excellent leaving group for various substitution and coupling reactions.

While specific proprietary synthesis routes may vary among manufacturers, a common approach to producing 4-Amino-3-bromobenzonitrile involves the selective bromination of a suitably substituted benzonitrile precursor. For instance, the bromination of 4-aminobenzonitrile under controlled conditions can yield the desired product. Alternatively, routes might involve the introduction of the nitrile group onto a bromoaniline derivative. As a leading manufacturer in China, we employ optimized synthesis protocols to ensure high purity (≥98.0%) and consistent quality for our 4-Amino-3-bromobenzonitrile, making us a preferred supplier for demanding applications.

In summary, a thorough understanding of the physical, chemical, and structural aspects of 4-Amino-3-bromobenzonitrile is vital for its effective utilization. If your work requires a high-quality, reliable source for this key organic intermediate, we encourage you to explore our offerings. We are dedicated to providing the chemical building blocks that drive innovation.