Understanding the synthesis and applications of key chemical intermediates is vital for professionals in the chemical and pharmaceutical industries. 4-Bromo-1-indanone, a compound with the CAS number 15115-60-3, is a prime example of such an essential building block, offering significant utility in various synthetic pathways.

Synthesis of 4-Bromo-1-indanone

The synthesis of 4-Bromo-1-indanone typically involves cyclization reactions starting from precursor molecules. One common method involves the intramolecular Friedel-Crafts acylation of appropriately substituted phenylpropionic acids. For instance, 3-(2-bromophenyl)propionic acid can be treated with a strong acid catalyst, such as trifluoromethanesulfonic acid or polyphosphoric acid, under heating conditions, leading to the desired indanone structure. Another approach may involve the use of Lewis acids like aluminum chloride in suitable solvents. Detailed procedures often highlight reaction conditions, purification steps (e.g., column chromatography), and yield optimizations. Manufacturers employ these refined methods to ensure the production of high-purity 4-Bromo-1-indanone, often achieving purities exceeding 98% or 99%.

Diverse Applications of 4-Bromo-1-indanone

The chemical structure of 4-Bromo-1-indanone, featuring both a reactive ketone and a bromine atom on an aromatic ring, makes it a versatile intermediate for a wide range of applications:

  • Pharmaceutical Intermediates: It is extensively used in the synthesis of various APIs, contributing to the development of drugs targeting conditions like cancer and inflammatory diseases. Researchers actively seek to buy 4-Bromo-1-indanone for its role in creating novel pharmaceutical entities.
  • Organic Synthesis: As a functionalized cyclic ketone, it serves as a valuable starting material for constructing more complex organic molecules, including heterocycles and fused ring systems.
  • Material Science: Its derivatives are explored for potential applications in polymers, specialty coatings, and other advanced materials, where specific electronic or structural properties are desired.
  • Agrochemicals: It can also be utilized in the synthesis pathways for certain pesticides and crop protection agents.

Sourcing and Partnership

For professionals looking to procure 4-Bromo-1-indanone, partnering with reliable manufacturers and suppliers is crucial. Key considerations include product purity, availability for bulk orders, competitive pricing, and comprehensive technical documentation. We pride ourselves on being a trusted manufacturer and supplier, offering high-quality 4-Bromo-1-indanone to meet the diverse needs of the chemical and pharmaceutical industries. Contact us to get a quote and explore how our commitment to quality and service can benefit your projects.