For professionals engaged in chemical research and industrial manufacturing, a deep understanding of a compound's properties and synthesis is fundamental. 4-Bromo-2-chlorophenol (CAS 3964-56-5) is a significant organic intermediate whose characteristics make it valuable in various synthetic pathways. This article provides an overview of its key chemical attributes and common synthesis routes, offering insights for R&D scientists and production managers looking to buy or utilize this compound.

The molecular formula of 4-Bromo-2-chlorophenol is C6H4BrClO, with a molecular weight of 207.45. As indicated by its specifications, it typically presents as white to off-white crystalline needles. Key physical properties include a melting point range of 47-49 °C and a boiling point of 232-235 °C. Its density is approximately 1.6170 g/cm³. While practically insoluble in water, it exhibits solubility in common organic solvents such as benzene and toluene. These properties are critical for understanding its behavior in chemical reactions and during purification processes.

The primary synthesis route for 4-Bromo-2-chlorophenol involves the electrophilic aromatic substitution of 2-chlorophenol with bromine. A typical method involves reacting 2-chlorophenol with a brominating agent, such as N-bromosuccinimide (NBS), in a suitable solvent like acetonitrile, often in the presence of a catalyst. The reaction conditions, including temperature and reaction time, are carefully controlled to ensure regioselectivity and maximize the yield of the desired product. Post-reaction workup usually involves quenching, extraction, washing, drying, and purification, often through techniques like column chromatography or recrystallization, to achieve the required purity, such as the common 99.5% MIN assay.

Beyond its role as a direct product, understanding these synthesis parameters is beneficial for buyers who need to assess the capabilities of potential manufacturers. When sourcing 4-Bromo-2-chlorophenol, inquiring about the synthesis methods and quality control measures employed by a supplier, particularly a manufacturer in China, can provide confidence in the product's integrity. This knowledge empowers procurement specialists to make informed decisions when comparing prices and assessing the overall value proposition from different suppliers.

In conclusion, the chemical and physical properties of 4-Bromo-2-chlorophenol, coupled with its established synthesis pathways, highlight its importance as a versatile intermediate. For companies looking to purchase this compound, partnering with experienced manufacturers who meticulously control synthesis processes ensures the delivery of high-purity material essential for successful organic synthesis applications. We encourage R&D professionals and production managers to reach out to us for detailed product information and to inquire about purchasing 4-Bromo-2-chlorophenol.