Understanding the fundamental chemistry of key intermediates is crucial for scientists and procurement professionals in the chemical industry. 4-Chloro-2-fluoronitrobenzene, identified by CAS number 700-37-8, is a significant aromatic compound that serves as a versatile building block in various synthetic processes, particularly within the pharmaceutical and agrochemical sectors.

Unpacking the Structure and Properties

At its core, 4-Chloro-2-fluoronitrobenzene is a benzene ring substituted with three functional groups: a chlorine atom at position 4, a fluorine atom at position 2, and a nitro group (-NO2) at position 1. Its molecular formula is C6H3ClFNO2, and it has a molecular weight of 175.54 g/mol. Physically, it is typically described as a pale yellow to light brown solid. Key physical properties include:

  • Melting Point: Approximately 48°C, indicating it is a solid at room temperature.
  • Boiling Point: Around 241.8°C at atmospheric pressure, though predicted values may vary slightly.
  • Density: Approximately 1.494 g/cm³, suggesting it is denser than water.
  • Flash Point: Typically greater than 110°C, indicating moderate flammability.

The presence of electronegative substituents (Cl, F, and NO2) significantly influences the electron distribution within the benzene ring, making it reactive towards nucleophilic aromatic substitution reactions. This reactivity is precisely what makes it a valuable intermediate.

Synthesis and Production Insights

The production of 4-Chloro-2-fluoronitrobenzene often involves a halogen replacement (metathesis) reaction. A common synthetic route utilizes 2,4-dichloronitrobenzene as the starting material, reacting it with a fluoride source, such as potassium fluoride (KF), often in the presence of a phase-transfer catalyst or a suitable solvent like sulfolane. The reaction is typically carried out under controlled temperature conditions to favor the replacement of one chlorine atom with fluorine. For instance, heating a mixture of 2,4-dichloronitrobenzene, potassium fluoride, and a catalyst at elevated temperatures (e.g., 170°C) for several hours can yield the desired product.

Why Source from a Reliable Manufacturer?

As a crucial intermediate, the quality and consistent supply of 4-Chloro-2-fluoronitrobenzene are vital. When you need to buy this compound, partnering with an experienced manufacturer ensures:

  • High Purity Products: Ensuring u226599.0% purity is critical for predictable reaction yields and the quality of downstream products.
  • Consistent Supply: A reliable supplier guarantees that your production processes will not be interrupted due to stockouts.
  • Competitive Pricing: Manufacturers often provide more competitive pricing, especially for bulk orders.
  • Safety Information: Access to comprehensive safety data (SDS) and hazard statements is essential for safe handling and compliance.

Conclusion

4-Chloro-2-fluoronitrobenzene (CAS 700-37-8) is a cornerstone intermediate in fine chemical synthesis. Its unique chemical properties and established synthesis routes make it indispensable for creating complex molecules. For businesses looking to procure this compound, selecting a reputable manufacturer and supplier is key to ensuring product quality and operational efficiency. As a trusted provider, we are equipped to meet your needs for this essential chemical intermediate.