The Chemistry of 4-chloropyridin-2-amine: Properties and Synthesis
For chemists and production managers, a thorough understanding of a chemical intermediate's properties is fundamental to its successful application. 4-chloropyridin-2-amine (CAS 19798-80-2) is a compound whose chemical characteristics make it highly valuable in organic synthesis. Familiarizing yourself with these properties can inform your purchasing decisions and optimize its use in your processes.
Physically, 4-chloropyridin-2-amine is presented as an off-white powder, a common form for many organic solids that facilitates handling and weighing in laboratory and industrial settings. Its molecular formula, C5H5ClN2, and molecular weight of 128.56000 indicate a relatively small, yet functionalized molecule. The compound exhibits a notable density of 1.326 g/cm³, and its melting point of 126-127ºC suggests it is a stable solid at room temperature, which is advantageous for storage and transportation. The boiling point of 240.8ºC and a flash point of 99.4ºC provide further insights into its thermal stability and safety parameters, important considerations for manufacturers looking to buy.
Chemically, the presence of both an amino group (-NH2) and a chlorine atom (-Cl) on the pyridine ring imparts significant reactivity to 4-chloropyridin-2-amine. The amino group can participate in nucleophilic reactions or act as a directing group, while the chlorine atom is amenable to various substitution reactions, such as nucleophilic aromatic substitution or cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig). These reactions are cornerstone methodologies in modern organic synthesis, allowing for the construction of diverse and complex molecular architectures.
When you are ready to purchase this intermediate, seeking out a reliable manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. ensures you receive a product with the specified purity and consistent chemical behavior. Understanding these chemical properties helps R&D scientists and product formulators better integrate 4-chloropyridin-2-amine into their synthesis schemes.
Perspectives & Insights
Agile Reader One
"4ºC provide further insights into its thermal stability and safety parameters, important considerations for manufacturers looking to buy."
Logic Vision Labs
"Chemically, the presence of both an amino group (-NH2) and a chlorine atom (-Cl) on the pyridine ring imparts significant reactivity to 4-chloropyridin-2-amine."
Molecule Origin 88
"The amino group can participate in nucleophilic reactions or act as a directing group, while the chlorine atom is amenable to various substitution reactions, such as nucleophilic aromatic substitution or cross-coupling reactions (e."