For chemists and R&D professionals, a deep understanding of chemical intermediates is crucial for successful synthesis and product development. 4-Fluoro-2-hydroxybenzoic Acid (CAS 345-29-9) is a prominent example of such a compound, valued for its specific chemical characteristics and broad applicability. This article explores the core chemical properties, common synthesis routes, and essential handling considerations for this important organic intermediate, positioning it as a reliable material for your industrial needs.

Key Chemical Properties and Characteristics

4-Fluoro-2-hydroxybenzoic Acid, with the molecular formula C7H5FO3 and a molecular weight of 156.11 g/mol, presents itself as a white solid. Its key physical properties include a melting point of approximately 170°C, indicating its stability at typical ambient temperatures. The compound exhibits good solubility in methanol, which is advantageous for many reaction conditions and purification processes. Its EINECS number is 206-459-5, and its CAS number, 345-29-9, uniquely identifies it within chemical databases. The presence of the fluorine atom, hydroxyl group, and carboxylic acid moiety on the benzene ring dictates its reactivity and its utility as a synthetic building block.

Synthesis Pathways: From Raw Materials to Intermediate

The synthesis of 4-Fluoro-2-hydroxybenzoic Acid often involves established organic chemistry reactions. One common route described in literature starts from 2,4-difluorobenzoic acid. In this process, a nucleophilic aromatic substitution reaction, typically using a base like sodium hydroxide in a polar aprotic solvent such as DMSO, replaces one of the fluorine atoms with a hydroxyl group. The reaction conditions, including temperature and reaction time, are optimized to ensure high yield and purity. Following the reaction, acidification and filtration are employed to isolate the final product. As a manufacturer, we employ optimized synthesis protocols to ensure consistent quality and purity, making us a dependable supplier for your procurement needs.

Handling, Storage, and Safety Considerations

Proper handling and storage are vital for maintaining the quality and integrity of chemical intermediates. 4-Fluoro-2-hydroxybenzoic Acid should be stored in a dry environment, ideally under an inert atmosphere if long-term storage is required, and at room temperature. Although generally stable, it's advisable to consult the Material Safety Data Sheet (MSDS) for specific safety precautions. Standard personal protective equipment (PPE), such as gloves, eye protection, and lab coats, should be used when handling the compound. Its hazard statements typically indicate potential for skin and eye irritation, underscoring the need for careful handling. When you purchase this chemical, always refer to the provided safety data for best practices.

Sourcing and Application Insights

For industries relying on this intermediate, understanding its supply chain is critical. Reputable manufacturers and suppliers, including those based in China, offer this compound with assured purity levels, often around 97%. Buyers can expect competitive pricing, especially for bulk orders, and the availability of samples for evaluation. The primary applications lie in the synthesis of pharmaceuticals and agrochemicals, where its unique structural features are highly valued. If you are looking to buy this versatile intermediate, engaging with experienced chemical suppliers will ensure you receive a high-quality product backed by technical support.

In summary, 4-Fluoro-2-hydroxybenzoic Acid is a compound of significant chemical interest, underpinned by its well-defined properties and accessible synthesis pathways. Its role as a key intermediate in pharmaceuticals and agrochemicals makes it an essential material for many industrial processes. By understanding its chemistry and sourcing it from reliable manufacturers, you can effectively integrate this compound into your synthesis strategies.