For chemists, formulators, and researchers, a deep understanding of the chemical properties and synthesis pathways of key compounds is fundamental. 4-Hydroxy-2-Methylbenzoic Acid (CAS 578-39-2) is one such compound, playing a significant role as an intermediate in various industrial applications. This article explores its chemical structure, synthesis methods, and the breadth of its applications.

Chemical Structure and Properties

4-Hydroxy-2-Methylbenzoic Acid, also known by synonyms such as 4-hydroxy-o-toluic acid, possesses the molecular formula C8H8O3 and a molecular weight of 152.15 g/mol. Its structure is characterized by a benzoic acid core with a hydroxyl group at the para position (position 4) and a methyl group at the ortho position (position 2) relative to the carboxylic acid group. This arrangement of functional groups imparts specific chemical reactivity, making it a valuable building block in organic synthesis.

The compound typically appears as a white to pale-colored crystalline powder, with a melting point generally recorded between 177-181°C. The presence of the hydroxyl and carboxylic acid groups makes it soluble in polar solvents like alcohols and water, facilitating its use in various reaction media. Its pKa value indicates it behaves as a weak acid.

Synthesis of 4-Hydroxy-2-Methylbenzoic Acid

While specific proprietary synthesis routes may vary, the production of 4-Hydroxy-2-Methylbenzoic Acid generally involves established organic chemistry principles. Potential synthesis approaches could include:

  • Carboxylation of Cresols: Similar to the Kolbe-Schmitt reaction used for salicylic acid, appropriate substituted cresols might be carboxylated under specific conditions to introduce the carboxylic acid group.
  • Oxidation of Corresponding Aldehydes or Alcohols: If a suitable methyl-substituted hydroxybenzaldehyde or benzyl alcohol is available, it could be oxidized to the carboxylic acid.
  • Functional Group Interconversion: Starting from related aromatic compounds, strategic introduction or modification of functional groups could lead to the target molecule.

As a dedicated manufacturer, we employ optimized and scalable synthesis routes to produce high-purity 4-Hydroxy-2-Methylbenzoic Acid, ensuring consistency and quality for our customers.

Diverse Applications

The chemical versatility of 4-Hydroxy-2-Methylbenzoic Acid lends itself to a range of applications:

  • Pharmaceutical Intermediates: It serves as a crucial building block for synthesizing various active pharmaceutical ingredients (APIs) and drug candidates.
  • Fine Chemical Synthesis: Its structure is valuable in creating specialty chemicals, dyes, and agrochemical intermediates.
  • Research and Development: It is widely used in academic and industrial research laboratories for developing new materials and chemical processes.

For those looking to buy 4-Hydroxy-2-Methylbenzoic Acid for their synthesis needs, understanding its chemistry ensures the optimal selection of reaction conditions and partner suppliers. We invite you to contact us for high-quality CAS 578-39-2 and to discuss your project requirements with our technical team.