In the realm of fine chemicals and pharmaceutical intermediates, understanding the synthesis and applications of specific compounds is key to innovation and efficient production. 4-Methylbenzyl Thiocyanate, identified by CAS number 18991-39-4, is one such compound that holds significant value for researchers and manufacturers. This article explores its chemical properties, various synthesis methodologies, and its critical role as a building block in complex organic synthesis.

Chemical Identity and Properties

4-Methylbenzyl Thiocyanate is an organic compound characterized by its chemical formula C₉H₉NS and a molecular weight of 163.24 g/mol. It features a thiocyanate functional group (-SCN) attached to a benzyl group, which in turn is substituted with a methyl group at the para position of the phenyl ring. This specific structure imparts unique chemical reactivity. While the provided data mentions it can be a yellowish liquid, other sources indicate it as a white powder, highlighting the importance of confirming specifications with your 4-methylbenzyl thiocyanate supplier.

Synthesis Methodologies for Accessibility

The accessibility of 4-Methylbenzyl Thiocyanate for industrial and research purposes is facilitated by several efficient synthetic routes:

  • Direct Thiocyanation: Modern methods include the AIBN-initiated direct thiocyanation of benzylic C-H bonds. This approach is highly efficient, often yielding up to 100% of the desired product without the need for pre-functionalized starting materials.
  • Phase Transfer Catalysis: Utilizing phase transfer catalysts with benzyl halides and metal thiocyanates offers another effective pathway. This method is often conducted under mild, environmentally friendly conditions, making it attractive for scalable production.
  • Microwave-Assisted Synthesis: Microwave irradiation significantly accelerates reactions between benzyl halides and zinc thiocyanate, leading to high yields and selectivity for thiocyanates. This technique is a modern approach to rapid chemical synthesis.

These varied synthesis techniques ensure that researchers and manufacturers can easily buy 4-methylbenzyl thiocyanate with confidence in its availability and quality. For companies seeking a reliable source, NINGBO INNO PHARMCHEM CO.,LTD. is a leading chemical synthesis provider in China.

Applications in Pharmaceutical and Organic Synthesis

The primary utility of 4-Methylbenzyl Thiocyanate lies in its role as a key intermediate in the pharmaceutical industry, particularly for the synthesis of Etoricoxib. Its structure makes it an excellent building block for various complex organic molecules. Researchers often utilize it in developing new synthetic methodologies and exploring the reactivity of organic thiocyanates. As a fine chemical intermediate manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. supplies this compound to research institutions and pharmaceutical companies worldwide.

Choosing a Trusted Manufacturer

When sourcing chemical intermediates, it is crucial to partner with a reputable supplier. NINGBO INNO PHARMCHEM CO.,LTD. is a distinguished 4-methylbenzyl thiocyanate supplier known for its commitment to quality and reliability. We offer competitive 4-methylbenzyl thiocyanate prices and ensure a stable supply chain for our clients globally. Whether you are conducting early-stage research or scaling up API production, we are equipped to meet your demands.

Conclusion

4-Methylbenzyl Thiocyanate is a valuable compound in the chemical industry, essential for pharmaceutical synthesis and organic research. Its efficient production methods and diverse applications underscore its importance. For those looking to purchase 4-methylbenzyl thiocyanate, NINGBO INNO PHARMCHEM CO.,LTD. provides high-purity products backed by expertise and a commitment to customer satisfaction. Contact us today to learn more about our product offerings and how we can support your chemical needs.