The Chemistry Behind 5-Chloro-2-methylaniline: Properties and Synthesis Explained
To fully appreciate the significance of 5-Chloro-2-methylaniline (CAS 95-79-4) in industrial chemistry, it's essential to understand its fundamental chemical properties and the common synthesis pathways employed by manufacturers. This aromatic amine derivative is a cornerstone intermediate, and a grasp of its characteristics is vital for R&D scientists and procurement specialists alike. As a committed chemical intermediate manufacturer in China, we aim to provide clarity on these aspects.
Chemically, 5-Chloro-2-methylaniline is characterized by its molecular formula C7H8ClN and a molecular weight of approximately 141.60 g/mol. It typically presents as a white to grayish-white solid, though it can appear as a pale yellow to brown liquid upon melting, with a melting point around 22°C. Its boiling point is approximately 237°C, and it exhibits limited solubility in water but is soluble in common organic solvents like ethanol and ether. The presence of the chlorine atom and the amino group influences its reactivity, making it susceptible to electrophilic aromatic substitution and diazotization reactions – key transformations in its industrial use.
The synthesis of 5-Chloro-2-methylaniline commonly begins with the chlorination of 2-methylaniline (o-toluidine). This process requires precise control over reaction parameters, such as temperature, the choice of chlorinating agent (e.g., chlorine gas), and the solvent used (e.g., carbon tetrachloride or dichloromethane), to ensure high yield and purity. Alternative routes might involve multistep synthesis starting from other benzene derivatives. The focus for any reputable manufacturer in China is to optimize these processes for efficiency, safety, and environmental responsibility.
Stability is another critical factor. Under normal temperatures and pressures, 5-Chloro-2-methylaniline is generally stable. However, it requires proper storage in tightly closed containers, in a cool, dry, and well-ventilated area, away from incompatible substances like strong oxidizers and acids. Understanding these conditions is crucial for maintaining product integrity throughout the supply chain, from our facility to the end-user.
For industries relying on this compound, such as dye manufacturing, pharmaceuticals, and agrochemicals, partnering with a reliable supplier of 5-chloro-2-methylaniline is paramount. We encourage professionals seeking high-quality CAS 95-79-4 to inquire about our product, its specifications, and our manufacturing capabilities. By understanding the chemistry and synthesis, you can make informed decisions when choosing a supplier to meet your critical chemical needs.
Perspectives & Insights
Core Pioneer 24
“Its boiling point is approximately 237°C, and it exhibits limited solubility in water but is soluble in common organic solvents like ethanol and ether.”
Silicon Explorer X
“The presence of the chlorine atom and the amino group influences its reactivity, making it susceptible to electrophilic aromatic substitution and diazotization reactions – key transformations in its industrial use.”
Quantum Catalyst AI
“The synthesis of 5-Chloro-2-methylaniline commonly begins with the chlorination of 2-methylaniline (o-toluidine).”