The synthesis and understanding of chemical intermediates are fundamental to progress in many scientific disciplines, especially in the pharmaceutical industry. 5-Pyridin-2-yl-1H-pyridin-2-one (CAS: 381233-78-9) is one such compound, valued for its unique heterocyclic structure and its utility in complex organic syntheses. As a dedicated supplier of fine chemicals, we provide insights into the chemistry of this important intermediate.

Key Chemical Properties and Structure

5-Pyridin-2-yl-1H-pyridin-2-one, with the CAS number 381233-78-9, possesses a molecular formula of C10H8N2O and a molecular weight of approximately 172.18 g/mol. Its structure features a pyridine ring linked to a 2-pyridone moiety. This combination of aromatic and heterocyclic rings imparts specific electronic and chemical properties. Typically appearing as a white solid, it exhibits moderate to good solubility in common organic solvents like DMSO and methanol, although sparingly soluble in chloroform. The compound's pKa is estimated around 10.85, indicating its weak basicity.

Synthesis Pathways and Procurement Considerations

The synthesis of 5-Pyridin-2-yl-1H-pyridin-2-one often involves established organic chemistry reactions. One common approach is the Suzuki coupling reaction, which allows for the formation of the crucial carbon-carbon bond between pyridine and pyridone rings. For instance, coupling reactions involving pyridyl boronic acid derivatives and halogenated pyridones are frequently employed. Researchers and procurement managers looking to buy this compound will find that many manufacturers, particularly in China, specialize in these synthesis routes. When considering a purchase, it's essential to inquire about the specific synthetic methodology used by the supplier, as this can impact purity and potential by-products. Engaging with a reliable manufacturer ensures that the product meets the required specifications for applications such as pharmaceutical intermediate synthesis.

Applications and Future Potential

Beyond its role as a pharmaceutical intermediate, the versatile structure of 5-Pyridin-2-yl-1H-pyridin-2-one may lend itself to other applications in materials science or as a ligand in coordination chemistry. However, its primary current use is in the development of therapeutics targeting neurological diseases. The ability to easily purchase this compound from dependable suppliers facilitates ongoing research and the scaling up of potential drug candidates.

Understanding the chemical intricacies of 5-Pyridin-2-yl-1H-pyridin-2-one, from its synthesis to its applications, empowers researchers and procurement specialists to make informed decisions when sourcing this vital chemical from manufacturers.