In the realm of organic synthesis, specific molecular structures serve as linchpins for creating more complex and valuable compounds. One such crucial molecule is 7-Bromo-2-methyl-1-indanone (CAS 213381-43-2), a brominated indanone derivative that plays a significant role as a pharmaceutical intermediate and a versatile building block in various chemical applications. Understanding its synthesis and reactivity is key for chemists and procurement professionals alike.

Understanding the Indanone Scaffold
The indanone structure, a bicyclic compound featuring a fused benzene and cyclopentanone ring system, is a privileged scaffold frequently found in natural products and pharmacologically active molecules. The presence of the ketone group and the aromatic ring provides multiple sites for chemical modification. When a bromine atom is strategically placed, as in 7-Bromo-2-methyl-1-indanone, its synthetic utility is greatly enhanced.

Synthetic Pathways to 7-Bromo-2-methyl-1-indanone
The synthesis of this valuable intermediate typically involves well-established organic chemistry principles. While specific proprietary methods may vary among manufacturers, common approaches include:

  • Friedel-Crafts Acylation: This classic reaction is a cornerstone for forming indanone rings. It often involves the cyclization of a suitably substituted arylpropionic acid derivative. For 7-Bromo-2-methyl-1-indanone, this might involve a precursor already bearing the bromine and methyl substituents in the correct positions, which then undergoes intramolecular acylation to form the desired bicyclic system.
  • Bromination of Precursors: Alternatively, a non-brominated methyl-indanone precursor can be synthesized first, followed by regioselective bromination. Achieving precise bromination at the 7-position requires careful control of reaction conditions and reagent selection to avoid unwanted isomers or side reactions.

Applications and Reactivity
The true value of 7-Bromo-2-methyl-1-indanone lies in its versatility as a synthetic intermediate. Its key features, particularly the reactive bromine atom and the indanone framework, enable a wide array of transformations:

  • Pharmaceutical Synthesis: As a pharmaceutical intermediate, it is crucial for the synthesis of various APIs. The bromine atom serves as an excellent leaving group or coupling partner in reactions like Suzuki-Miyaura coupling or Buchwald-Hartwig amination, allowing for the introduction of diverse functional groups necessary for biological activity.
  • Agrochemicals: Its structural motif can be incorporated into the development of novel agrochemicals, contributing to advancements in crop protection and agricultural productivity.
  • Materials Science: The compound's unique electronic and structural properties make it a candidate for use in the development of advanced materials, including organic electronics and specialty polymers.

Reliable Sourcing from China
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Conclusion
7-Bromo-2-methyl-1-indanone is a testament to the power of well-designed chemical intermediates. Its strategic synthesis and diverse reactivity make it an invaluable tool for chemists across multiple disciplines. We invite researchers and procurement professionals to explore the possibilities this compound offers and to partner with us for a consistent and high-quality supply.