(S)-N-tert-Butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CAS: 149182-72-9) is a fascinating molecule within the realm of fine chemical intermediates, primarily recognized for its critical role in the pharmaceutical industry. This chiral compound, characterized by its tetrahydroisoquinoline core and a tert-butyl amide functional group, possesses specific stereochemistry that makes it indispensable for the synthesis of complex, biologically active molecules. Understanding its chemical properties and synthesis pathways is key for researchers and manufacturers looking to procure this intermediate effectively.

Chemically, (S)-N-tert-Butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide typically presents as an off-white crystalline powder, indicating a stable solid form suitable for handling and storage. Its molecular formula is C14H20N2O, with a molecular weight of 232.32 g/mol. The compound's optical activity, specified by the (S) configuration, is crucial as it dictates the stereochemistry of the final drug products synthesized from it. This specificity is a hallmark of advanced pharmaceutical intermediates, where enantiomeric purity is often a critical quality attribute. Procurement managers seeking to buy this compound should always verify the enantiomeric excess (ee) to ensure suitability for their target application.

The synthesis of (S)-N-tert-Butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide often involves sophisticated organic chemistry techniques, ensuring the preservation of its chiral integrity. Common routes might include the coupling of chiral amino acids or their derivatives with tert-butylamine or related reagents. The ability to reliably produce this molecule in high yields and purity is a testament to the advanced capabilities of chemical manufacturers. For companies looking to purchase this intermediate, inquiring about the specific synthesis routes and the purity analysis methods used by the supplier can provide valuable insights into product quality and consistency. This is particularly relevant for those who need to buy in bulk for large-scale production.

The primary application of (S)-N-tert-Butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide lies in its function as a key intermediate in the synthesis of several important pharmaceuticals. It is notably used in the production of certain antidepressant drugs and antihypertensive agents. The demand for these medications drives the market for this specific intermediate. Therefore, identifying a reliable manufacturer and supplier that can consistently deliver this product is a strategic imperative for pharmaceutical companies aiming to secure their raw material supply chain. If you are in need of this compound, consider reaching out to established suppliers for a competitive price and detailed product information.