The Chemistry and Applications of (3-Chloro-5-cyanophenyl)boronic Acid
In the realm of specialized organic chemistry, certain molecules stand out for their versatility and essential role in constructing complex architectures. (3-Chloro-5-cyanophenyl)boronic acid, a white powder with a purity often exceeding 98.0%, is a prime example. This compound, cataloged under CAS number 915763-60-9, is a valuable reagent for chemists and researchers engaged in sophisticated synthesis, particularly within the pharmaceutical and agrochemical industries. Understanding its chemical nature and applications is key for any professional looking to leverage its potential.
At its core, (3-Chloro-5-cyanophenyl)boronic acid is a derivative of phenylboronic acid, featuring a chloro group at the 3-position and a cyano group at the 5-position of the phenyl ring. This specific arrangement of functional groups dictates its reactivity. The boronic acid moiety (-B(OH)2) makes it an excellent coupling partner in Suzuki-Miyaura reactions, a cornerstone of modern carbon-carbon bond formation. The presence of the electronegative chlorine atom and the electron-withdrawing cyano group can influence the electronic properties and reactivity of the molecule, offering chemists finer control during synthetic transformations.
The primary application driving demand for (3-Chloro-5-cyanophenyl)boronic acid is its use as a pharmaceutical intermediate. It serves as a crucial building block for synthesizing a range of therapeutic agents. The ability to introduce specific substituted phenyl rings into larger molecules via cross-coupling makes it invaluable in drug discovery, enabling the creation of novel drug candidates with tailored biological activities. For instance, it might be employed in the synthesis of compounds targeting specific disease pathways, where the precise placement of substituents is critical for efficacy and selectivity.
Beyond pharmaceuticals, this boronic acid derivative finds utility in materials science. Its structure can be incorporated into polymers or other advanced materials to impart specific electronic or optical properties. Researchers exploring new functional materials for electronics, sensors, or coatings might utilize such compounds as monomers or functionalizing agents. When seeking to purchase this material, focusing on suppliers who can guarantee high assay purity ensures that the material performs predictably in these sensitive applications.
For chemical manufacturers and procurement specialists, ensuring a consistent and high-quality supply of (3-Chloro-5-cyanophenyl)boronic acid is essential. Working with a reputable supplier in China provides access to competitive pricing and a reliable source of this critical intermediate. Understanding the detailed specifications, safe handling procedures, and storage requirements is part of responsible chemical management. Ultimately, the utility of (3-Chloro-5-cyanophenyl)boronic acid in creating sophisticated organic molecules underscores its importance as a key chemical intermediate.
Perspectives & Insights
Quantum Pioneer 24
“Understanding its chemical nature and applications is key for any professional looking to leverage its potential.”
Bio Explorer X
“At its core, (3-Chloro-5-cyanophenyl)boronic acid is a derivative of phenylboronic acid, featuring a chloro group at the 3-position and a cyano group at the 5-position of the phenyl ring.”
Nano Catalyst AI
“The boronic acid moiety (-B(OH)2) makes it an excellent coupling partner in Suzuki-Miyaura reactions, a cornerstone of modern carbon-carbon bond formation.”