In the intricate world of organic chemistry and pharmaceutical manufacturing, certain molecules stand out for their versatile utility and critical role in complex synthesis. 7-Chloro-2-methylquinoline, identified by CAS number 4965-33-7, is one such compound. This quinoline derivative serves as an indispensable building block, particularly within the pharmaceutical industry, and understanding its chemical characteristics and applications is crucial for researchers and manufacturers alike.

Chemical Profile and Properties

7-Chloro-2-methylquinoline (C10H8ClN) possesses a molecular weight of 177.63 g/mol. It presents as a pale yellow to light beige crystalline powder, a physical state that is conducive to various handling and reaction processes. Its melting point typically falls between 74-78°C, and it exhibits a boiling point of 87°C at 0.5 mmHg. The compound's structure features a quinoline ring substituted with a chlorine atom at the 7th position and a methyl group at the 2nd position. This specific arrangement of functional groups dictates its reactivity and its utility in targeted organic synthesis.

The solubility of 7-Chloro-2-methylquinoline is noted as slight in both chloroform and methanol. While seemingly minor, these solubility characteristics are important for chemists when designing reaction and purification protocols. Manufacturers specializing in fine chemicals and pharmaceutical intermediates, such as NINGBO INNO PHARMCHEM CO.,LTD., focus on producing this compound with high purity (often exceeding 99%) to ensure its efficacy in downstream applications.

Synthesis and Manufacturing Excellence

The synthesis of 7-Chloro-2-methylquinoline typically involves controlled chlorination processes. Manufacturers aim for optimized production routes that ensure high yields and exceptional purity. Advanced techniques, including continuous flow chemistry and precise control over reaction parameters like temperature and pressure, are employed to meet the stringent demands of the pharmaceutical sector. Companies that invest in state-of-the-art manufacturing facilities and expertise in these areas are well-positioned as reliable suppliers for this critical intermediate.

Diverse Applications in Modern Chemistry

The primary application of 7-Chloro-2-methylquinoline is its role as a key intermediate in the synthesis of pharmaceuticals. Its most prominent use is in the production of Montelukast Sodium Salt, an essential drug for treating asthma and allergies. Beyond this, its quinoline scaffold makes it valuable for the research and development of other medicinal compounds, potentially targeting conditions such as malaria and certain types of cancer. Its structural versatility also lends itself to applications in broader organic synthesis, where it can be modified to create novel compounds with specific properties for research purposes or advanced materials.

For businesses looking to buy 7-Chloro-2-methylquinoline, partnering with a reputable manufacturer or supplier in China offers access to high-quality products at competitive prices. Ensuring the material is sourced responsibly and meets all required specifications is vital for the success of any synthesis project.

In summary, 7-Chloro-2-methylquinoline is more than just a chemical intermediate; it is a foundational component enabling significant advancements in pharmaceutical research and development. Its consistent availability and high purity are critical for researchers and manufacturers striving to create innovative solutions for global health challenges.