Fmoc-L-Methionine Sulfone, identified by its CAS number 163437-14-7, is a sophisticated derivative of the amino acid methionine, crucial for advanced chemical synthesis. Its structure combines the well-established Fmoc (9-fluorenylmethoxycarbonyl) protecting group with a methionine residue where the sulfur atom has been oxidized to a sulfone. This unique combination imbues the molecule with specific chemical properties that make it highly valuable in scientific research, particularly in the realms of peptide synthesis and drug discovery.

The Fmoc group is a cornerstone of modern solid-phase peptide synthesis (SPPS). It provides a base-labile protection for the alpha-amino group, allowing for iterative coupling of amino acids under mild conditions. The subsequent removal of the Fmoc group with piperidine unmasks the amino terminus for the next coupling step, a cycle that is fundamental to building complex peptide chains. The presence of the sulfone group in Fmoc-L-Methionine Sulfone is also significant. Oxidation to the sulfone state can alter the electronic and steric properties of the amino acid side chain. This can lead to increased stability against oxidative degradation, improved solubility in various solvent systems, and potentially different conformational preferences in the resulting peptides. Researchers often choose this derivative when seeking to enhance the robustness or modify the biophysical characteristics of their target peptides. When you need to buy such specialized reagents, understanding these chemical distinctions is key.

The applications of Fmoc-L-Methionine Sulfone are broad and impactful. In peptide synthesis, it is employed to introduce a modified methionine residue into a peptide sequence. This can be useful for creating peptides with improved stability, altered binding affinities, or specific functionalities. For instance, in drug development, incorporating such modified amino acids can lead to peptide therapeutics with enhanced pharmacological properties, such as longer circulation times or increased target specificity. The ability to purchase high-quality Fmoc-L-Methionine Sulfone from reliable manufacturers like Ningbo Inno Pharmchem ensures that these complex synthetic efforts can be undertaken with confidence.

Beyond direct peptide synthesis, Fmoc-L-Methionine Sulfone finds utility in bioconjugation. The sulfone moiety can serve as a reactive handle or influence the overall polarity of the molecule, facilitating conjugation to other biomolecules, polymers, or solid supports. This is critical for developing advanced drug delivery systems, diagnostic tools, and novel biomaterials. The demand for such specialized intermediates underscores the importance of a robust chemical supply chain, where manufacturers can provide consistent quality and competitive prices for this key building block.

In essence, Fmoc-L-Methionine Sulfone (CAS 163437-14-7) represents a powerful tool for synthetic chemists. Its carefully designed structure enables precise control in peptide synthesis, supports innovative drug discovery, and opens avenues for advanced bioconjugation. For any researcher or organization involved in these fields, understanding its chemical advantages and sourcing it from trusted manufacturers is a critical step towards achieving scientific breakthroughs.