Procaine Base, identified by its CAS number 59-46-1, is a compound that bridges historical medical practice with contemporary pharmaceutical innovation. This white crystalline powder, recognized for its anesthetic properties, remains a compound of interest for its chemical structure and its utility as a pharmaceutical intermediate. Understanding its chemistry and applications is crucial for professionals in the pharmaceutical and chemical industries.

Chemically, Procaine Base is an ester derivative of p-aminobenzoic acid and 2-diethylaminoethanol. Its molecular formula is C13H20N2O2, with a molecular weight of approximately 236.31 g/mol. The presence of an ester linkage makes it susceptible to hydrolysis, particularly in alkaline conditions, which is a key factor in its metabolism and stability considerations. Its mechanism of action as a local anesthetic involves the reversible blockade of voltage-gated sodium channels, preventing the transmission of nerve impulses and thus providing pain relief.

Historically, Procaine Base was widely used as Novocain, a primary local anesthetic in dentistry and minor surgical procedures. Although newer agents with longer durations of action or reduced allergic potential have largely supplanted it in some clinical settings, Procaine Base continues to be valued for specific applications and as a reference compound in anesthetic research. Furthermore, its role extends to being a pharmaceutical intermediate. Its chemical structure can be modified or used as a scaffold for the synthesis of other active pharmaceutical ingredients (APIs). Emerging research also points to its potential as a DNA-demethylating agent, opening doors for investigation into its use in cancer therapy and epigenetics.

For manufacturers and suppliers like NINGBO INNO PHARMCHEM CO.,LTD., producing Procaine Base involves stringent quality control to achieve high purity levels, typically above 99%. This ensures that the product is suitable for its intended pharmaceutical applications. The manufacturing process, often involving esterification and subsequent reduction, requires precise control of reaction conditions and purification steps to yield a high-quality product.

Procurement professionals seeking Procaine Base will find that working directly with manufacturers offers advantages in terms of price and consistent supply. Understanding the technical specifications, handling requirements (such as protection from moisture), and packaging standards (often hermetically sealed containers) is essential for maintaining product integrity. When purchasing in bulk, negotiating pricing directly with a reputable manufacturer in China can provide significant cost benefits.

In essence, Procaine Base (CAS 59-46-1) represents a vital link in the pharmaceutical supply chain. Its well-defined chemical properties, historical significance, and evolving research applications make it a compound of continued importance. Ensuring a reliable source of high-purity Procaine Base is fundamental for pharmaceutical development and manufacturing.