The intricate world of organic chemistry is built upon foundational molecules that serve as versatile intermediates for a vast array of applications. Among these, 2-Chloro-5-(trifluoromethyl)benzonitrile (CAS 328-87-0) stands out due to its unique chemical structure and reactivity, making it a cornerstone for advancements in pharmaceuticals, agrochemicals, and materials science. NINGBO INNO PHARMCHEM CO.,LTD. is a leading provider of this compound, offering insights into its synthesis and properties. Understanding the 2-Chloro-5-trifluoromethylbenzonitrile uses begins with appreciating its chemical makeup.

The synthesis of 2-Chloro-5-(trifluoromethyl)benzonitrile typically involves multi-step processes that carefully introduce the chloro, trifluoromethyl, and nitrile functional groups onto a benzene ring. These processes are optimized to ensure high yields and purity, crucial for its role as a CAS 328-87-0 pharmaceutical intermediate. The electron-withdrawing nature of both the trifluoromethyl and nitrile groups significantly influences the reactivity of the aromatic ring, making it susceptible to specific nucleophilic and electrophilic substitution reactions.

Key properties of 2-Chloro-5-(trifluoromethyl)benzonitrile include its appearance as a white to off-white crystalline powder, with a melting point typically around 37-41°C. Its molecular formula is C8H3ClF3N, and it possesses a molecular weight of approximately 205.56 g/mol. These physical and chemical characteristics are vital for handling, storage, and effective integration into various synthetic pathways, including those employed in trifluoromethylbenzonitrile agrochemical synthesis.

The trifluoromethyl group, in particular, is a critical feature. It enhances lipophilicity, which is beneficial for drug absorption and membrane permeability in pharmaceuticals, and for penetration into target organisms in agrochemicals. It also contributes to metabolic stability, prolonging the active life of the final product. This makes the compound a highly sought-after intermediate for its role in various fluorinated aromatic intermediate applications.

NINGBO INNO PHARMCHEM CO.,LTD., as a reputable manufacturer and supplier from China, is committed to delivering 2-Chloro-5-(trifluoromethyl)benzonitrile that adheres to stringent purity standards. Our expertise in chemical synthesis ensures that we can provide reliable and high-quality intermediates for your research and manufacturing needs. We invite you to explore the chemical potential of this versatile compound and partner with us to drive innovation in your respective fields.