In the intricate world of organic chemistry, certain molecules stand out for their versatility and potential to unlock new frontiers in synthesis. 2-Fluoro-5-iodobenzonitrile (CAS 351003-36-6) is one such compound, prized by R&D scientists for its unique reactivity and its role as a sophisticated building block. Understanding its chemical structure, synthesis pathways, and key reaction mechanisms is essential for harnessing its full potential. As a dedicated manufacturer, we are proud to supply this compound to fuel innovation.

The chemical identity of 2-Fluoro-5-iodobenzonitrile is defined by its formula C7H3FIN and its CAS number 351003-36-6. The molecule features a benzene ring substituted with three functional groups: a fluorine atom at the 2-position, an iodine atom at the 5-position, and a nitrile group (-CN) at the 1-position. This specific arrangement dictates its chemical behavior. The fluorine atom, being highly electronegative, influences the electron distribution within the aromatic ring, potentially affecting the reactivity of other substituents. The iodine atom, a relatively large and polarizable halogen, serves as an excellent leaving group in nucleophilic substitution reactions and is particularly amenable to transition-metal-catalyzed cross-coupling reactions. The nitrile group is a versatile functional handle that can be readily transformed into other important moieties, such as carboxylic acids, amines, or amides, through various chemical transformations.

The synthesis of 2-Fluoro-5-iodobenzonitrile itself typically involves multi-step organic reactions, often starting from simpler aromatic precursors. Precise control over reaction conditions is necessary to achieve high regioselectivity and yield, ensuring the desired substitution pattern. Manufacturers employ advanced synthetic methodologies and rigorous quality control to produce this compound at high purity, often specified as 98% purity 2-Fluoro-5-iodobenzonitrile.

The true value of 2-Fluoro-5-iodobenzonitrile lies in its reactivity as a building block. Its iodine substituent is a prime site for cross-coupling reactions. For example, Suzuki coupling with boronic acids, Stille coupling with organostannanes, or Sonogashira coupling with terminal alkynes can efficiently introduce new carbon-carbon bonds at the 5-position. These reactions are fundamental in constructing complex molecular architectures, making it an indispensable tool for drug discovery and material science. Researchers frequently seek to buy 2-Fluoro-5-iodobenzonitrile pharmaceutical intermediate for its direct application in building novel drug candidates.

Furthermore, the fluorine atom's presence can significantly impact the pharmacokinetic and pharmacodynamic properties of the resulting molecules, enhancing lipophilicity, metabolic stability, or binding affinity. The nitrile group's potential for transformation adds another layer of versatility, allowing for diverse functionalization. This makes 2-Fluoro-5-iodobenzonitrile a strategic choice for chemists aiming to fine-tune molecular properties for specific applications.

For product formulators and R&D scientists, procuring 2-Fluoro-5-iodobenzonitrile from a reliable manufacturer and supplier is crucial. Understanding the compound's chemical behavior allows for more efficient experimental design and process optimization. Whether engaging in complex multi-step synthesis or seeking a unique building block for novel applications, this fluorinated iodobenzonitrile offers a powerful platform for chemical innovation. We encourage inquiries about its chemical properties and applications, and are ready to discuss its price and availability for your next project.