The Chemistry Behind 3-(Trifluoromethoxy)aniline: Properties and Synthesis
Understanding the intrinsic chemical and physical properties of a compound is the cornerstone of its effective utilization in research and industrial applications. 3-(Trifluoromethoxy)aniline (CAS: 1535-73-5) is no exception. This organic intermediate, characterized by its unique trifluoromethoxy substituent, exhibits properties that make it highly valuable across various sectors, particularly in pharmaceuticals and agrochemicals.
From a physical standpoint, 3-(Trifluoromethoxy)aniline is typically described as a colorless to yellow or orange clear liquid. Its density is around 1.325 g/mL at 25°C, and it has a boiling point of approximately 72-73°C at 8 mmHg. The refractive index (n20/D) is noted to be around 1.466. These properties are critical for chemists when designing reaction conditions and purification methods. For instance, its liquid state at room temperature simplifies handling and addition in reaction vessels. Furthermore, its solubility in common organic solvents like ethyl acetate and chloroform aids in reaction setup and workup procedures.
Chemically, the presence of the trifluoromethoxy group (-OCF3) is what sets 3-(trifluoromethoxy)aniline apart. This electron-withdrawing group influences the reactivity of the aromatic ring and the amine functionality, making it a versatile precursor for a multitude of reactions. It's this chemical reactivity that enables its use in synthesizing complex fluorinated molecules. Researchers frequently inquire about '3-(trifluoromethoxy)aniline properties' and 'synthesis of 3-(trifluoromethoxy)aniline' to gauge its suitability for specific projects.
While detailed synthesis routes are often proprietary, general methods involve the fluorination of precursor molecules. For those looking to integrate this compound into their workflow, understanding these fundamental properties is key. Sourcing from a reputable chemical manufacturer that provides comprehensive technical documentation, such as Safety Data Sheets (SDS) and Certificates of Analysis (COA), ensures that you are working with a reliable material that meets the required specifications for your demanding applications.
Perspectives & Insights
Bio Analyst 88
“While detailed synthesis routes are often proprietary, general methods involve the fluorination of precursor molecules.”
Nano Seeker Pro
“For those looking to integrate this compound into their workflow, understanding these fundamental properties is key.”
Data Reader 7
“Sourcing from a reputable chemical manufacturer that provides comprehensive technical documentation, such as Safety Data Sheets (SDS) and Certificates of Analysis (COA), ensures that you are working with a reliable material that meets the required specifications for your demanding applications.”