Understanding the fundamental chemistry of a compound is crucial for its effective application in synthesis and material design. 4-Ethynylaniline, identified by CAS number 14235-81-5, is a fascinating molecule with a rich chemical profile that makes it highly valuable across various scientific disciplines. Its structure features an aromatic ring substituted with both an amine group (-NH2) and an ethynyl group (-C≡CH), bestowing upon it unique reactivity and versatility.

The presence of the amine group renders 4-Ethynylaniline nucleophilic and basic, allowing it to participate in reactions typical of anilines, such as acylation, alkylation, and diazotization. Crucially, the ethynyl group is a terminal alkyne, known for its susceptibility to addition reactions and its participation in cycloaddition reactions, most notably the CuAAC 'click' reaction. This dual functionality is what makes it such a prized building block for chemists. The specific position of these groups on the benzene ring influences the molecule's electronic properties and reactivity, impacting its performance in various synthetic pathways.

From a physical properties standpoint, 4-Ethynylaniline is typically observed as a yellow to brown crystalline powder, with a melting point in the range of 98-102 °C (with decomposition). This solid form at room temperature, coupled with its reactive functional groups, makes it convenient for handling and storage, provided appropriate conditions are maintained. Ensuring that the supplier provides accurate melting point data and purity information is vital for successful implementation in synthesis.

The synthesis of 4-Ethynylaniline can involve several organic transformations, often starting from readily available aniline derivatives or aromatic precursors. Common routes might include palladium-catalyzed coupling reactions or Sonogashira couplings to introduce the ethynyl group onto an appropriately substituted aniline or protected aniline. For industrial-scale production, efficiency, yield, and cost-effectiveness are key considerations for manufacturers. When sourcing this compound, knowing that it comes from a dedicated manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. assures adherence to strict quality and synthesis protocols.

For those seeking to buy 4-Ethynylaniline or learn more about its synthesis and applications, understanding its chemical nuances is the first step. Its role as a pharmaceutical intermediate, a click chemistry reagent, and a precursor for advanced materials underscores its importance in modern chemistry. We invite you to explore our offerings and contact us for detailed specifications and pricing information.