Understanding the chemical intricacies of key reagents is fundamental for effective research and development. Boc-D-His(Tos)-OH·DCHA, a protected D-histidine derivative, is a prime example of a specialty chemical that requires detailed knowledge of its properties and synthesis. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated manufacturer, aims to shed light on the chemistry that makes this compound so valuable for peptide synthesis professionals.

The molecular structure of Boc-D-His(Tos)-OH·DCHA is characterized by a D-histidine core. The 'Boc' (tert-butoxycarbonyl) group is attached to the alpha-amino nitrogen, providing acid-labile protection. Crucially, the imidazole ring of histidine is protected by a 'Tos' (p-toluenesulfonyl) group. This tosyl group is more robust, offering protection against a wider range of reaction conditions, yet it can be cleaved under specific conditions, offering synthetic flexibility. The entire molecule is presented as a dicyclohexylammonium (DCHA) salt, which typically enhances the compound's solid-state properties, including improved crystallinity and solubility in organic solvents used for peptide synthesis. For those looking to buy Boc-D-His(Tos)-OH·DCHA, understanding these structural elements is key to appreciating its utility.

The synthesis of Boc-D-His(Tos)-OH·DCHA typically involves a multi-step process starting from D-histidine. Initial steps usually involve protecting the alpha-amino group with the Boc anhydride reagent and the imidazole nitrogen with p-toluenesulfonyl chloride. These reactions require careful control of pH and temperature to ensure regioselectivity and minimize side products. The final step often involves forming the DCHA salt, which aids in the isolation and purification of the product. As a leading Boc-D-His(Tos)-OH·DCHA manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. employs optimized synthesis routes to ensure high yield and purity, making us a reliable CAS 210694-29-4 supplier.

The chemical properties of Boc-D-His(Tos)-OH·DCHA are directly linked to its utility in peptide synthesis. The presence of the carboxylic acid group allows it to readily participate in amide bond formation with the amine terminus of a growing peptide chain, typically mediated by coupling reagents. The protecting groups ensure that only the desired coupling occurs. Researchers often seek wholesale Boc-D-His(Tos)-OH·DCHA prices to manage costs for larger synthesis projects. The stability of the tosyl group, while protecting the imidazole, is a key feature that distinguishes it from other histidine derivatives.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing detailed technical information and high-quality Boc-D-His(Tos)-OH·DCHA for research and industrial applications. We understand that consistent quality is vital for reliable results in peptide synthesis, whether for academic exploration or large-scale production of therapeutic peptides. Partner with us for your needs of advanced peptide synthesis building blocks and experience the difference that quality and expertise make.