The development of effective pharmaceuticals is a testament to sophisticated chemical engineering and a deep understanding of molecular interactions. For antifungal agents like Itraconazole, the journey from raw materials to a life-saving drug involves intricate synthetic pathways. At the heart of this process lies a critical intermediate: 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one, commonly identified by CAS No. 106461-41-0. This compound is not just another chemical; it's a precisely designed molecular scaffold essential for building the complex structure of Itraconazole.

Chemically, CAS 106461-41-0 is characterized by its triazole ring system, a piperazine moiety, and a phenyl group, culminating in a hydroxyl-substituted phenyl ring. This specific arrangement of functional groups is what makes it an ideal precursor for the synthesis of Itraconazole. The triazole ring, in particular, is a hallmark of many azole antifungals, contributing significantly to their mechanism of action by inhibiting fungal cytochrome P450 enzymes. When considering the purchase of this intermediate, understanding its structural integrity is vital for downstream success.

The manufacturing process for this triazole derivative is crucial. Pharmaceutical researchers and manufacturers require materials with a minimum purity of 98.0% to ensure that the subsequent synthetic steps are clean and efficient. Impurities in the intermediate can lead to undesired byproducts, reduced yields, and potential safety concerns in the final drug product. This is why reputable suppliers, often located in regions like China known for their chemical manufacturing prowess, emphasize high purity and robust quality control. For those engaged in pharmaceutical R&D, obtaining this intermediate for testing and synthesis development is a critical first step.

Beyond its direct role in Itraconazole synthesis, understanding the properties of this intermediate, such as its appearance (typically an off-white to pale brown solid) and melting point (around 177-179°C), provides valuable insights for handling and storage. These physical characteristics, alongside its precise chemical structure, underscore its importance in the chemical synthesis landscape. For companies seeking to establish a reliable supply chain for this compound, engaging with manufacturers who can guarantee both quality and consistency is paramount. The availability of such high-grade pharmaceutical intermediates directly fuels innovation and production in the fight against fungal infections.