The development of effective pharmaceuticals relies heavily on the understanding and application of specific chemical compounds. 2-[1-(Mercaptomethyl)cyclopropyl]acetic acid, bearing the CAS number 162515-68-6, is a prime example of a critical chemical intermediate whose properties are intimately linked to its vital function in the synthesis of Montelukast, a cornerstone medication for managing asthma and allergic rhinitis. This article explores the key chemical and physical attributes of this compound and explains why these characteristics make it indispensable for pharmaceutical manufacturers.

At its core, 2-[1-(Mercaptomethyl)cyclopropyl]acetic acid is an organic acid with the molecular formula C6H10O2S and a molecular weight of approximately 146.21 g/mol. These fundamental properties define its reactivity and how it behaves in chemical reactions. The presence of the mercaptomethyl group (-SH) and the carboxylic acid group (-COOH) on a cyclopropyl ring system provides specific sites for chemical transformations. This structural arrangement is precisely what makes it an ideal precursor for Montelukast, facilitating key coupling reactions that build the final drug molecule efficiently. The 'chemical synthesis' of such intermediates requires precision, and NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of developing optimized processes for this compound.

Physically, 2-[1-(Mercaptomethyl)cyclopropyl]acetic acid typically presents as a white crystalline solid. Its melting point, generally observed in the range of 42-45°C, indicates it is a solid at room temperature but can melt relatively easily. This property is important for handling and processing, as it influences solubility and reaction conditions. The compound's solubility in methanol is another key characteristic, aiding in its purification and use in various reaction media. Furthermore, its predicted pKa of 4.76±0.10 signifies its acidic nature, which plays a role in its chemical behavior during synthesis.

The industrial production of such pharmaceutical intermediates demands adherence to strict quality standards. Manufacturers rely on suppliers like NINGBO INNO PHARMCHEM CO.,LTD. to provide material that consistently meets specifications. Factors such as residual solvents, heavy metals, and specific reaction by-products are carefully controlled. The purity of the 2-[1-(Mercaptomethyl)cyclopropyl]acetic acid directly impacts the yield and quality of the final Montelukast API. Therefore, detailed analytical data, including GC and HPLC chromatograms, are often requested by buyers to verify the compound's integrity.

In essence, the chemical and physical properties of 2-[1-(Mercaptomethyl)cyclopropyl]acetic acid are not mere data points; they are critical determinants of its utility and value in the pharmaceutical industry. As a key intermediate for Montelukast, its specific structure, purity, and reactivity are fundamental to producing a drug that offers relief to millions suffering from respiratory ailments. NINGBO INNO PHARMCHEM CO.,LTD. is committed to ensuring that these essential properties are maintained, supporting the continuous advancement of pharmaceutical chemistry.