Understanding the chemical profile of a pharmaceutical intermediate is fundamental to its effective use in research and development. SB525334, identified by CAS number 356559-20-1, is a complex organic molecule that serves as a potent TGF-β Receptor I (ALK5) inhibitor. A deep dive into its chemical properties reveals why it is such a valuable tool for scientists.

The molecular formula of SB525334 is C21H21N5, with a molecular weight of approximately 343.425 g/mol. This structure, featuring a quinoxaline core with tert-butyl and methyl-pyridine substituents, is designed for precise interaction with the ALK5 kinase domain. The compound's physical appearance is typically described as a yellow solid, with a melting point around 159 °C. Its stability is noted as being stable for two years from the date of purchase when stored correctly, typically at 2-8 °C.

From a chemical perspective, SB525334's selectivity for ALK5 over other related kinases like ALK2, ALK3, and ALK6 is a key feature. This selectivity translates to more focused research outcomes when studying the TGF-beta signaling pathway. The compound's solubility, for instance, in DMSO (≥20mg/mL), is critical for preparing solutions for various experimental setups. Its acidity factor (pKa) of 10.24±0.10 (predicted) also provides insights into its behavior in different chemical environments.

NINGBO INNO PHARMCHEM CO.,LTD., as a leading manufacturer in China, ensures that the SB525334 we supply meets high purity standards (typically 97%+) and adheres to these critical chemical specifications. This reliability is essential for researchers who depend on the consistent performance of their chemical reagents. Understanding these properties allows scientists to optimize experimental conditions and interpret results accurately.

For those looking to buy SB525334 and delve into its chemical intricacies, NINGBO INNO PHARMCHEM CO.,LTD. is your trusted partner. We provide detailed product information and high-quality pharmaceutical intermediates to support your research. Explore the chemistry of targeted inhibition with our reliable supply of SB525334.