The Chemistry Behind Ticagrelor: An In-Depth Look at 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine
The journey from basic chemical compounds to life-saving pharmaceuticals is a testament to the power of organic chemistry and meticulous manufacturing processes. Ticagrelor, a cornerstone in antiplatelet therapy, relies on a series of precisely synthesized intermediates, with 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine (CAS: 145783-15-9) playing a pivotal role. Understanding the chemistry and application of this specific intermediate is key to appreciating the complexity of modern drug production.
4,6-Dichloro-2-(propylthio)pyrimidin-5-amine is characterized by its pyrimidine core, functionalized with two chlorine atoms at the 4 and 6 positions, and a propylthio group at the 2 position, along with an amine group at the 5 position. This specific arrangement of functional groups makes it an ideal precursor for subsequent chemical transformations required in the synthesis of Ticagrelor. The presence of the chlorine atoms, for instance, often serves as reactive sites for nucleophilic substitution reactions, a common strategy in constructing complex organic molecules. The propylthio group contributes specific electronic and steric properties that are crucial for the final drug's interaction with its biological target.
The production of this intermediate requires careful control over reaction conditions to achieve the desired purity and yield. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. prioritize high assay percentages (e.g., ≥98.0%) and consistent product appearance (yellow to yellowish brown oily matter or solid) to meet the exacting standards of the pharmaceutical industry. The pursuit of reliable 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine is driven by the understanding that even minor impurities can have significant consequences on the downstream synthesis and the final drug's performance and safety profile. Therefore, the buy decision for such intermediates is heavily influenced by supplier reputation and quality assurance protocols.
The significance of this intermediate is amplified by the growing global incidence of thrombotic events. Ticagrelor's effectiveness in preventing such events makes it a highly sought-after medication. Consequently, the demand for its key intermediates, including 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, remains robust. NINGBO INNO PHARMCHEM CO.,LTD. actively contributes to meeting this demand by providing a consistent and high-quality supply. Our role as a manufacturer and supplier underscores the importance of specialized chemical knowledge in supporting advancements in cardiovascular medicine. For accurate pharmaceutical intermediate supplier information and pricing inquiries, engaging with reputable manufacturers is the first step.
In essence, the chemistry of 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine is fundamental to the successful and efficient synthesis of Ticagrelor. Its precise molecular architecture and the commitment to its quality by manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. are indispensable for delivering effective treatments to patients worldwide.
4,6-Dichloro-2-(propylthio)pyrimidin-5-amine is characterized by its pyrimidine core, functionalized with two chlorine atoms at the 4 and 6 positions, and a propylthio group at the 2 position, along with an amine group at the 5 position. This specific arrangement of functional groups makes it an ideal precursor for subsequent chemical transformations required in the synthesis of Ticagrelor. The presence of the chlorine atoms, for instance, often serves as reactive sites for nucleophilic substitution reactions, a common strategy in constructing complex organic molecules. The propylthio group contributes specific electronic and steric properties that are crucial for the final drug's interaction with its biological target.
The production of this intermediate requires careful control over reaction conditions to achieve the desired purity and yield. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. prioritize high assay percentages (e.g., ≥98.0%) and consistent product appearance (yellow to yellowish brown oily matter or solid) to meet the exacting standards of the pharmaceutical industry. The pursuit of reliable 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine is driven by the understanding that even minor impurities can have significant consequences on the downstream synthesis and the final drug's performance and safety profile. Therefore, the buy decision for such intermediates is heavily influenced by supplier reputation and quality assurance protocols.
The significance of this intermediate is amplified by the growing global incidence of thrombotic events. Ticagrelor's effectiveness in preventing such events makes it a highly sought-after medication. Consequently, the demand for its key intermediates, including 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, remains robust. NINGBO INNO PHARMCHEM CO.,LTD. actively contributes to meeting this demand by providing a consistent and high-quality supply. Our role as a manufacturer and supplier underscores the importance of specialized chemical knowledge in supporting advancements in cardiovascular medicine. For accurate pharmaceutical intermediate supplier information and pricing inquiries, engaging with reputable manufacturers is the first step.
In essence, the chemistry of 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine is fundamental to the successful and efficient synthesis of Ticagrelor. Its precise molecular architecture and the commitment to its quality by manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. are indispensable for delivering effective treatments to patients worldwide.
Perspectives & Insights
Core Pioneer 24
“Ticagrelor's effectiveness in preventing such events makes it a highly sought-after medication.”
Silicon Explorer X
“Consequently, the demand for its key intermediates, including 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, remains robust.”
Quantum Catalyst AI
“actively contributes to meeting this demand by providing a consistent and high-quality supply.”