N-Carbobenzyloxy-L-glutamine (Z-Gln-OH), identified by CAS number 2650-64-8, is more than just a chemical compound; it's a critical enabler in modern organic synthesis, particularly within the fields of peptide chemistry and pharmaceutical development. As a leading manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. provides this high-purity intermediate, understanding its fundamental role in creating complex biomolecules.

The synthesis of Z-Gln-OH typically involves the protection of the alpha-amino group of L-glutamine with a carbobenzyloxy (Cbz) group. This process is carefully controlled to ensure high yields and purity, making it an ideal starting material for further chemical transformations. The Cbz group is chosen for its stability under a range of reaction conditions, yet it can be readily removed via methods like catalytic hydrogenation, a key feature that allows for controlled stepwise addition of amino acids during peptide synthesis. This protected form is crucial for preventing side reactions and ensuring the regioselective formation of peptide bonds.

Key Chemical Aspects and Applications:

  • Protection Strategy: The Cbz protecting group on Z-Gln-OH shields the amine functionality, allowing the carboxyl group to react selectively in peptide coupling reactions. This methodical approach is central to achieving high purity in synthesized peptides.
  • Role in Peptide Synthesis: As a fundamental pharmaceutical intermediate, Z-Gln-OH is used to incorporate glutamine residues into peptide chains. This is vital for creating peptides that mimic natural biological sequences or possess therapeutic properties, such as hormones, growth factors, and enzyme inhibitors. Researchers often look to purchase Z-Gln-OH for these specific applications.
  • Broader Chemical Synthesis: Beyond peptides, Z-Gln-OH can serve as a valuable building block in the synthesis of various organic molecules where a protected glutamine moiety is required. Its well-defined chemical properties make it a versatile reagent for organic chemists.
  • Sourcing High-Quality Material: For consistent results, it is imperative to buy Z-Gln-OH from a reputable manufacturer and supplier. We ensure that our product meets stringent purity specifications, guaranteeing its suitability for demanding applications. Whether you need it for lab-scale research or industrial production, we are your reliable partner.

Understanding the chemistry behind Z-Gln-OH empowers chemists to leverage its properties effectively. Our commitment as a leading Z-Gln-OH supplier is to provide the research and industrial communities with this essential, high-purity compound, facilitating advancements in chemistry and medicine. Explore our capabilities and secure your supply of Z-Gln-OH today.