Understanding the Chemistry: Boc-L-2-Nitrophenylalanine Properties
The efficacy of any chemical compound in research and development hinges on its intrinsic properties and the precision of its synthesis. Boc-L-2-Nitrophenylalanine is no exception. As a protected amino acid derivative, understanding its chemical characteristics is fundamental for its optimal use in peptide synthesis, drug discovery, and various biotechnological applications. NINGBO INNO PHARMCHEM CO.,LTD. emphasizes the importance of these properties for its clients.
The core structure of Boc-L-2-Nitrophenylalanine combines L-phenylalanine with two key modifications: the tert-butyloxycarbonyl (Boc) group and a nitro group (-NO2) on the phenyl ring at the ortho (2-) position. The Boc group is an acid-labile protecting group for the alpha-amino group. This means it can be selectively removed under mild acidic conditions, such as treatment with trifluoroacetic acid (TFA) or HCl, without affecting other sensitive parts of a growing peptide chain. This controlled deprotection is a cornerstone of solid-phase peptide synthesis (SPPS). The molecular formula is C14H18N2O6, and its molecular weight is approximately 310.3 g/mol.
The nitro group introduces electron-withdrawing properties to the phenyl ring. This can influence the overall electronic character and reactivity of the side chain. It also provides a handle for further chemical transformations. For example, the nitro group can be reduced to an amine, which can then be used for coupling reactions, the introduction of fluorescent labels, or conjugation to other molecules. This reactivity makes Boc-L-2-Nitrophenylalanine a versatile intermediate for creating complex molecular architectures.
Purity is a critical parameter for Boc-L-2-Nitrophenylalanine. In peptide synthesis, even small amounts of impurities can lead to truncated sequences, deletion sequences, or side products that are difficult to remove, compromising the final peptide's integrity and biological activity. Therefore, obtaining Boc-L-2-Nitrophenylalanine with high purity (typically >97% or >98%) is essential. NINGBO INNO PHARMCHEM CO.,LTD. ensures rigorous quality control throughout the manufacturing process to guarantee the purity and consistency of our product, allowing researchers to buy with confidence.
The physical properties also play a role. Boc-L-2-Nitrophenylalanine is generally described as a white to off-white solid or powder. Proper storage conditions, typically at 2-8°C, are necessary to maintain its stability and prevent degradation. Understanding these chemical and physical properties allows scientists to effectively design synthetic strategies and troubleshoot any issues that may arise. For those looking to purchase Boc-L-2-Nitrophenylalanine, partnering with a supplier that provides detailed technical specifications and Certificates of Analysis (CoA) is highly recommended.
NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality Boc-L-2-Nitrophenylalanine, backed by comprehensive technical support, ensuring that researchers have the reliable materials they need for their advanced chemical synthesis projects.
The core structure of Boc-L-2-Nitrophenylalanine combines L-phenylalanine with two key modifications: the tert-butyloxycarbonyl (Boc) group and a nitro group (-NO2) on the phenyl ring at the ortho (2-) position. The Boc group is an acid-labile protecting group for the alpha-amino group. This means it can be selectively removed under mild acidic conditions, such as treatment with trifluoroacetic acid (TFA) or HCl, without affecting other sensitive parts of a growing peptide chain. This controlled deprotection is a cornerstone of solid-phase peptide synthesis (SPPS). The molecular formula is C14H18N2O6, and its molecular weight is approximately 310.3 g/mol.
The nitro group introduces electron-withdrawing properties to the phenyl ring. This can influence the overall electronic character and reactivity of the side chain. It also provides a handle for further chemical transformations. For example, the nitro group can be reduced to an amine, which can then be used for coupling reactions, the introduction of fluorescent labels, or conjugation to other molecules. This reactivity makes Boc-L-2-Nitrophenylalanine a versatile intermediate for creating complex molecular architectures.
Purity is a critical parameter for Boc-L-2-Nitrophenylalanine. In peptide synthesis, even small amounts of impurities can lead to truncated sequences, deletion sequences, or side products that are difficult to remove, compromising the final peptide's integrity and biological activity. Therefore, obtaining Boc-L-2-Nitrophenylalanine with high purity (typically >97% or >98%) is essential. NINGBO INNO PHARMCHEM CO.,LTD. ensures rigorous quality control throughout the manufacturing process to guarantee the purity and consistency of our product, allowing researchers to buy with confidence.
The physical properties also play a role. Boc-L-2-Nitrophenylalanine is generally described as a white to off-white solid or powder. Proper storage conditions, typically at 2-8°C, are necessary to maintain its stability and prevent degradation. Understanding these chemical and physical properties allows scientists to effectively design synthetic strategies and troubleshoot any issues that may arise. For those looking to purchase Boc-L-2-Nitrophenylalanine, partnering with a supplier that provides detailed technical specifications and Certificates of Analysis (CoA) is highly recommended.
NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality Boc-L-2-Nitrophenylalanine, backed by comprehensive technical support, ensuring that researchers have the reliable materials they need for their advanced chemical synthesis projects.
Perspectives & Insights
Data Seeker X
“Therefore, obtaining Boc-L-2-Nitrophenylalanine with high purity (typically >97% or >98%) is essential.”
Chem Reader AI
“ensures rigorous quality control throughout the manufacturing process to guarantee the purity and consistency of our product, allowing researchers to buy with confidence.”
Agile Vision 2025
“Boc-L-2-Nitrophenylalanine is generally described as a white to off-white solid or powder.”