Bis(2-oxo-3-oxazolidinyl)phosphinic chloride, widely recognized by its acronym BOP-Cl (CAS: 68641-49-6), is a specialized chemical compound that has garnered significant attention in the field of organic synthesis. Its unique chemical properties make it an invaluable tool for chemists, particularly in the demanding realm of peptide synthesis. For researchers and chemical manufacturers seeking to buy this reagent, understanding its core characteristics is fundamental to leveraging its full potential.

At its heart, BOP-Cl is a phosphinic acid derivative, characterized by its molecular formula C6H8ClN2O5P and a molecular weight of approximately 254.57 g/mol. It typically appears as an off-white to white crystalline powder, with a purity often specified at ≥99.0%. This high level of purity is crucial for achieving reliable and reproducible results in sensitive chemical reactions. Its physical properties, such as a melting point around 191°C, indicate a stable compound under standard laboratory conditions, although it is noted to be sensitive to moisture and will hydrolyze in water, necessitating careful storage and handling.

The primary utility of BOP-Cl lies in its exceptional performance as a polypeptide condensing agent. It functions by activating the carboxyl group of an amino acid, transforming it into a more reactive species, typically a mixed anhydride. This activated carboxyl group can then readily form a peptide bond with the amino group of another amino acid. One of the most significant advantages of BOP-Cl is its ability to suppress epimerization during peptide coupling. This means it helps maintain the stereochemical configuration of chiral amino acids, a critical factor in synthesizing biologically active peptides and pharmaceuticals. Researchers often turn to BOP-Cl when traditional coupling agents like carbodiimides prove less effective, especially with sterically hindered amino acids.

Beyond its prominent role in peptide synthesis, BOP-Cl also serves as a versatile reagent for forming other derivatives, such as esters, thioesters, and amides, making it a valuable asset in broader organic synthesis. For manufacturers looking to source this compound, it is important to find a reputable supplier in China that can guarantee consistent quality and availability. The economic advantages and advanced manufacturing capabilities found in China make it a prime location for procuring high-performance chemical intermediates like BOP-Cl.

In summary, the chemical properties of Bis(2-oxo-3-oxazolidinyl)phosphinic chloride, particularly its high purity and efficacy in minimizing epimerization, position it as a superior condensing agent. For scientists and industrial chemists, understanding these attributes empowers informed decisions when selecting reagents for complex synthetic challenges, ensuring the successful creation of valuable chemical compounds.