In the ongoing battle against cardiovascular diseases, the pharmaceutical industry plays a pivotal role, often through the development of highly effective medications that manage critical health markers like cholesterol levels. At the heart of many of these life-changing drugs lies a complex interplay of chemistry, where specific intermediates are essential for achieving the desired therapeutic outcome. Ethyl (S)-4-Chloro-3-Hydroxybutyrate (CAS 86728-85-0) is one such intermediate, acting as a crucial molecular building block in the synthesis of Atorvastatin, a leading statin medication.

Cholesterol management is a cornerstone of preventative cardiology. High cholesterol levels are a significant risk factor for heart disease, stroke, and other serious health conditions. Atorvastatin works by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol production in the liver. The effectiveness and safety of Atorvastatin are intrinsically linked to its specific three-dimensional molecular structure, a characteristic known as chirality. This is where Ethyl (S)-4-Chloro-3-Hydroxybutyrate becomes indispensable. Its precise stereochemistry is a prerequisite for constructing the correct enantiomer of Atorvastatin, ensuring that the drug interacts optimally with its biological target.

The chemical nature of Ethyl (S)-4-Chloro-3-Hydroxybutyrate contributes to its utility. Supplied as a light yellow liquid, it possesses a molecular formula of C6H11ClO3 and a molecular weight of 166.603 g/mol. These characteristics, combined with a high purity level typically exceeding 99%, make it a reliable and consistent raw material for pharmaceutical synthesis. The presence of both a chloro and a hydroxyl group on its carbon chain provides reactive sites that are expertly manipulated through advanced synthetic pathways. For manufacturers aiming to produce high-quality Atorvastatin, sourcing pure Ethyl S-4-Chloro-3-Hydroxybutyrate is a primary concern.

The production of such a specialized chiral intermediate requires meticulous attention to detail and advanced manufacturing capabilities. Leading chemical companies, particularly those in Asia, have invested significantly in developing efficient and stereoselective synthesis processes. These manufacturers not only ensure high purity but also adhere to strict quality control protocols, often backed by certifications like ISO and GMP. This focus on quality assurance is vital, as any impurity or incorrect stereochemistry in the intermediate can compromise the final drug product.

The demand for Ethyl (S)-4-Chloro-3-Hydroxybutyrate is closely tied to the global market for cholesterol-lowering medications. With an aging global population and increasing awareness of cardiovascular health, the market for Atorvastatin and similar drugs remains robust. This sustained demand fuels the need for reliable suppliers of key intermediates. Companies looking for the best price for Ethyl S-4-Chloro-3-Hydroxybutyrate must balance cost with the critical need for consistent quality and supply chain reliability.

In essence, Ethyl (S)-4-Chloro-3-Hydroxybutyrate exemplifies the foundational role that specialized chemical intermediates play in modern medicine. Its contribution to the synthesis of Atorvastatin directly impacts the health and well-being of millions worldwide, highlighting the sophisticated chemistry that underpins effective disease management and treatment.