For professionals in the pharmaceutical and chemical industries, a deep understanding of key compounds is essential for successful research, development, and manufacturing. 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine, identified by CAS number 161599-46-8, is one such compound, primarily recognized for its critical role as an intermediate in the synthesis of Capecitabine. This article delves into its chemical properties, synthesis, and significance for B2B buyers and researchers.

Chemical Profile of CAS 161599-46-8
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine is a modified nucleoside derivative. Its molecular formula is C13H16FN3O6, and it has a molecular weight of approximately 329.28 g/mol. Typically appearing as a white to off-white solid, this compound is known for its role as a precursor in the production of Capecitabine, an important antineoplastic agent used in chemotherapy. The presence of acetyl groups on the 2' and 3' hydroxyl positions and the fluorine atom at the 5-position of the cytosine base are key features of its structure, critical for its function in Capecitabine synthesis.

Synthesis and Manufacturing Considerations
The synthesis of 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine generally involves the acetylation of 5'-deoxy-5-fluorocytidine. This process is carried out under controlled chemical conditions by specialized manufacturers. For businesses looking to purchase this intermediate, understanding the synthesis process can help in evaluating the purity and quality of the product. Suppliers often provide detailed specifications regarding purity levels, such as ≥98% or ≥99% by HPLC, along with information on solubility and melting point (typically around 196-198°C). These parameters are crucial for ensuring its suitability in downstream pharmaceutical processes.

Applications and Importance in Pharmaceutical Manufacturing
The primary and most critical application of 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine is its use as a key intermediate in the synthesis of Capecitabine. Capecitabine is a prodrug that is converted into 5-Fluorouracil within the body, acting as an anticancer agent. Therefore, any disruption in the supply or quality of this intermediate can directly impact the availability of this important medication. Pharmaceutical companies that manufacture Capecitabine API rely on a steady and reliable supply of high-purity CAS 161599-46-8.

Sourcing and Quality Assurance
When procuring 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine, B2B professionals should seek out experienced manufacturers and suppliers who can guarantee consistent quality and purity. Companies from regions like China are significant players in the global market for such pharmaceutical intermediates, offering competitive pricing and extensive manufacturing capabilities. It is vital to review supplier credentials, request detailed product documentation, and inquire about storage and handling recommendations to maintain the integrity of the compound. Accessing competitive pricing for bulk purchases is also a key consideration for API manufacturers.

In conclusion, 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine is a vital chemical entity in the pharmaceutical landscape, indispensable for the production of Capecitabine. For industry professionals, a thorough understanding of its chemical properties, synthesis, and the importance of sourcing from reputable suppliers is crucial for successful drug development and manufacturing operations.