In the intricate world of organic chemistry, certain molecules stand out for their versatility and importance in driving innovation, particularly within the pharmaceutical industry. (R)-Boc-3-Methoxy-Beta-Phe-OH, a compound characterized by its CAS number 499995-77-6, is one such molecule. Its unique chemical structure and protective group make it a valuable reagent for researchers and manufacturers alike.

Understanding the Molecular Structure and Properties

(R)-Boc-3-Methoxy-Beta-Phe-OH is an N-protected amino acid derivative. The 'Boc' (tert-butyloxycarbonyl) group is a widely used protecting group in peptide synthesis and organic chemistry. It temporarily masks the reactivity of the amine group, allowing other chemical transformations to occur selectively elsewhere in the molecule. The '3-Methoxy-Beta-Phe' portion refers to a phenylalanine derivative with a methoxy group at the meta-position of the phenyl ring, attached via a beta-carbon linkage. This specific arrangement provides unique steric and electronic properties.

Key properties often cited include:

  • Appearance: Typically a white to off-white powder.
  • Purity: High purity, often exceeding 99% as determined by HPLC, is essential for its applications.
  • Molecular Formula: C15H21NO5.
  • Molecular Weight: Approximately 295.331 g/mol.

Applications Driving Innovation

The primary applications of (R)-Boc-3-Methoxy-Beta-Phe-OH lie in fields requiring precise molecular construction:

  • Peptide Synthesis: As a non-proteinogenic amino acid derivative, it is used to introduce specific structural modifications into peptides. This can alter their biological activity, stability, or pharmacokinetic properties, crucial for developing novel peptide-based therapeutics.
  • Medicinal Chemistry: In drug discovery, medicinal chemists utilize such building blocks to synthesize novel small molecules. The methoxyphenyl group can influence binding affinities to biological targets, and the overall structure contributes to the exploration of new chemical spaces for drug candidates.
  • Organic Synthesis: Beyond pharmaceuticals, it can serve as a chiral synthon in the construction of complex organic molecules where precise stereochemistry and functional group manipulation are required.

Procuring (R)-Boc-3-Methoxy-Beta-Phe-OH: A Global Perspective

When seeking to buy (R)-Boc-3-Methoxy-Beta-Phe-OH, researchers and procurement managers often turn to established chemical manufacturers and suppliers. China has become a significant hub for the production of such fine chemicals. Key considerations when sourcing this compound include ensuring high purity (≥ 99% HPLC), competitive pricing, and a reliable supply chain. Manufacturers are able to offer this material with consistent quality, suitable for both research quantities and larger-scale production needs.

Conclusion

(R)-Boc-3-Methoxy-Beta-Phe-OH represents a valuable tool in the chemist's arsenal, enabling advancements in peptide science and drug discovery. By understanding its chemical attributes and sourcing it from reputable global manufacturers, researchers can effectively harness its potential to drive scientific innovation.