Itopride (CAS 122898-67-3) stands as a significant molecule in the pharmaceutical landscape, primarily recognized for its efficacy in enhancing gastrointestinal motility. Understanding its chemical foundation—from its synthesis pathways to its mechanism of action—is crucial for anyone involved in its procurement, research, or application. This article explores the chemistry of Itopride, offering insights valuable to R&D scientists, formulators, and procurement specialists.

The chemical identity of Itopride is defined by its molecular formula C20H26N2O4 and a molecular weight of 358.43. Typically appearing as a white powder, its structure is characterized by a substituted benzamide core linked via a methylene bridge to a phenyl ring, which further incorporates a dimethylaminoethoxy side chain. This unique structure underpins its pharmacological activity.

The synthesis of Itopride is a multi-step organic process. Common routes involve the reaction of a substituted benzoic acid derivative with an appropriately functionalized benzylamine. For instance, one pathway might involve the coupling of 3,4-dimethoxybenzoic acid or its activated form (like an acid chloride) with N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]amine. Manufacturers focus on optimizing these reactions to maximize yield and purity, often achieving levels of 99% or higher. The choice of catalysts, solvents, and purification techniques (e.g., crystallization) plays a critical role in the quality of the final Itopride intermediate.

Therapeutically, Itopride functions as a prokinetic agent. It enhances gastrointestinal motility by antagonizing peripheral dopamine D2 receptors and inhibiting acetylcholinesterase. This leads to an increase in acetylcholine concentration, which stimulates upper gastrointestinal movements. Consequently, Itopride is prescribed for conditions such as functional dyspepsia, heartburn, and other disorders associated with delayed gastric emptying.

For those looking to purchase Itopride, understanding these chemical and functional aspects is vital. When sourcing from a Chinese Itopride manufacturer, it's imperative to verify the purity, batch consistency, and availability of technical documentation. The Itopride price should be considered alongside these quality indicators. A reliable supplier will provide detailed specifications and support for your R&D or manufacturing needs.

Key chemical and application insights:

  • Molecular Structure: Substituted benzamide with a key side chain for pharmacological activity.
  • Synthesis: Multi-step organic synthesis requiring precise control.
  • Purity: High purity (≥99%) is essential for pharmaceutical applications.
  • Mechanism: Dual action as a dopamine D2 antagonist and acetylcholinesterase inhibitor.
  • Therapeutic Use: Treatment of gastrointestinal motility disorders.

By appreciating the chemistry and application of Itopride, pharmaceutical professionals can make more informed decisions when selecting suppliers and integrating this important intermediate into their product pipelines.