In the realm of biochemical compounds driving advancements in health and longevity, Nicotinamide Riboside Chloride (NR-Cl), identified by CAS 23111-00-4, stands out. As a precursor to Nicotinamide Adenine Dinucleotide (NAD+), it plays a pivotal role in cellular energy metabolism, DNA repair, and regulating various cellular processes that are fundamental to healthy aging. For researchers, formulators, and procurement specialists, understanding the chemical nature and sourcing of NR-Cl is key to leveraging its potential.

Chemical Profile and Significance

Nicotinamide Riboside Chloride is a water-soluble vitamin B3 derivative. Its molecular structure allows it to be efficiently converted into NAD+ within cells. This conversion is crucial because NAD+ levels decline with age, impacting cellular function and contributing to age-related diseases. The chemical significance of NR-Cl lies in its ability to replenish these vital NAD+ stores. Typically appearing as a white or off-white powder, its purity, often exceeding 99%, is a critical parameter for its application in research and high-end product formulations. When sourcing, verifying this purity through reliable Certificates of Analysis (CoA) from the manufacturer is a standard practice.

The Role of NR-Cl in Research and Development

Scientists are extensively studying NR-Cl for its multifaceted benefits. Its capacity to enhance mitochondrial function, support sirtuin activity (proteins linked to longevity), and potentially improve cognitive and cardiovascular health makes it a compound of immense research interest. For laboratories and R&D departments, securing a consistent supply of high-quality NR-Cl is essential for reproducible results. This involves identifying suppliers who can not only provide the required purity but also offer granular details on stability, handling, and storage – typically in dry, cool conditions away from light.

Procurement Strategies for NR-Cl

For organizations looking to buy Nicotinamide Riboside Chloride in bulk, strategic sourcing is vital. Manufacturers, particularly those based in regions like China, offer competitive pricing and economies of scale. When evaluating potential suppliers, consider:

  • Manufacturing Expertise: Prioritize manufacturers with a proven track record in producing pharmaceutical-grade intermediates.
  • Quality Control: Ensure robust quality control measures are in place, leading to consistent product specifications.
  • Supply Chain Stability: Reliable delivery and inventory management are crucial for uninterrupted projects.
  • Customer Support: Responsive communication and technical assistance from the supplier can greatly facilitate the procurement process.

By understanding the chemical properties and adopting a strategic approach to sourcing, businesses can effectively acquire Nicotinamide Riboside Chloride to drive innovation in the health and longevity sectors. Its role as a biochemical cornerstone for NAD+ enhancement ensures its continued importance in scientific and commercial applications.