For chemists and R&D scientists working in the fine chemical and pharmaceutical industries, a deep understanding of key intermediates is crucial for successful synthesis and product development. Methyl Isobutyrylacetate (MIBA), identified by CAS number 42558-54-3, is one such compound that plays a significant role, particularly as an atorvastatin intermediate. This article delves into the chemical characteristics, synthesis considerations, and diverse applications of MIBA, providing valuable insights for professionals looking to buy Methyl Isobutyrylacetate.

Chemically, Methyl Isobutyrylacetate is a beta-keto ester with the molecular formula C7H12O3 and a molecular weight of 144.17 g/mol. Its physical appearance is that of a colorless transparent liquid, with a density of approximately 1.013 g/mL at 20°C. Key physical properties include a boiling point of 55-57°C at 15 hPa and a melting point of -75°C. Its solubility in water is moderate, around 43.6 g/L at 20°C, and it is generally stored under cool, dry conditions to prevent moisture absorption. These properties are vital for chemists to consider during reaction design and formulation processes.

The synthesis of MIBA often involves sophisticated chemical reactions. While specific patented methods vary, common pathways involve the reaction of isobutyryl chloride with acetonitrile followed by esterification. NINGBO INNO PHARMCHEM CO., LTD., a leading Methyl Isobutyrylacetate supplier China, employs advanced synthesis techniques to ensure high purity and yield. Challenges in MIBA production can include separating it from by-products with similar boiling points, necessitating optimized reaction pathways and efficient purification methods. For researchers and synthesis chemists, understanding these synthesis challenges can inform their choice of high purity MIBA for pharmaceutical synthesis.

The primary application for MIBA is as a crucial intermediate in the synthesis of Atorvastatin Calcium, a blockbuster drug used to manage hyperlipidemia and reduce the risk of cardiovascular events. Its role in forming a key part of the atorvastatin molecule makes it indispensable for pharmaceutical manufacturers. Beyond this, MIBA can also serve as a versatile building block in broader organic synthesis, enabling the creation of various heterocyclic compounds and other complex molecules. For those looking to procure this essential chemical, the Methyl Isobutyrylacetate price will vary based on purity and quantity, with reliable manufacturers offering competitive rates.

For scientists and developers, sourcing MIBA from a dependable atorvastatin intermediate manufacturer is key to experimental success. Engaging with suppliers who can provide consistent quality, detailed technical specifications, and timely delivery ensures that research and development projects proceed without interruption.