Nisoldipine, identified by its CAS number 63675-72-9, is a fascinating molecule that plays a critical role as a pharmaceutical intermediate in the synthesis of various therapeutic agents, most notably those targeting cardiovascular conditions. Understanding its chemical structure, properties, and typical synthesis routes provides valuable insight into its importance in the pharmaceutical industry. As a dedicated supplier of high-purity chemicals, we aim to illuminate the journey of Nisoldipine from laboratory synthesis to its eventual incorporation into life-saving medications.

The chemical nomenclature for Nisoldipine reveals its intricate structure: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-methylpropyl)ester. This name breaks down its core components: a dihydropyridine ring system, substituted with methyl groups at positions 2 and 6, a 2-nitrophenyl group at position 4, and ester linkages at positions 3 and 5, featuring methyl and 2-methylpropyl (isobutyl) functionalities. Its molecular formula is C20H24N2O6, and it has a molecular weight of approximately 388.41 g/mol. Typically supplied as light tan crystals, its physical form is a testament to the precision of its synthesis.

The primary utility of Nisoldipine lies in its role as a precursor for dihydropyridine calcium channel blockers. These APIs are vital in treating hypertension (high blood pressure) and angina pectoris (chest pain due to reduced blood flow to the heart). The dihydropyridine core is crucial for blocking voltage-gated L-type calcium channels in vascular smooth muscle and cardiac cells. This blockage leads to relaxation of blood vessels, a reduction in cardiac workload, and ultimately, improved blood pressure control and relief from angina symptoms.

The synthesis of Nisoldipine itself is a complex process, often involving multi-step organic reactions. While specific proprietary routes may vary between manufacturers, common pathways typically involve a Hantzsch dihydropyridine synthesis or related variations. This often entails the condensation of an aldehyde (in this case, 2-nitrobenzaldehyde), a beta-keto ester, and ammonia or an ammonia source, alongside other functionalized precursors to form the specific ester linkages. The meticulous control of reaction conditions, purification steps, and analytical verification is essential to achieve the high purity (>99%) demanded for pharmaceutical intermediates. When you buy Nisoldipine, you are investing in a product that has undergone significant chemical transformation and rigorous quality control.

For researchers and pharmaceutical manufacturers, sourcing Nisoldipine (CAS 63675-72-9) means acquiring a precisely engineered molecule. Understanding its chemical journey underscores the importance of partnering with reliable manufacturers and suppliers. Companies looking for Nisoldipine price quotations should also inquire about the synthetic route and the supplier's commitment to process optimization and impurity profiling. A manufacturer dedicated to chemical excellence ensures that each batch of Nisoldipine meets the exacting standards required for drug development.

In summary, the chemistry of Nisoldipine (CAS 63675-72-9) is central to its function as a key pharmaceutical intermediate. Its sophisticated structure, derived through carefully controlled synthesis, enables the creation of essential cardiovascular medications. As a leading supplier, we are proud to provide this critical building block, contributing to advancements in healthcare worldwide. If you require Nisoldipine for your research or manufacturing needs, exploring options with experienced Chinese suppliers will provide both quality and value.