Understanding the chemical properties and synthesis of critical intermediates is fundamental for anyone involved in pharmaceutical research and manufacturing. (2R,3S)-3-Phenylisoserine, identified by its CAS number 136561-53-0, is a compound that demands attention due to its essential role in complex organic syntheses, notably the production of Taxol. This article delves into the chemical characteristics and general synthesis considerations for this important chiral molecule, offering insights from a manufacturer's perspective.

From a structural standpoint, (2R,3S)-3-Phenylisoserine is a derivative of isoserine, featuring a phenyl group attached at the 3-position and specific stereochemistry at the 2 and 3 carbons (2R,3S). Its molecular formula is C9H11NO3, giving it a molecular weight of approximately 181.19 g/mol. Physically, it typically appears as a white powder, a characteristic that aids in its handling and quality assessment. The density is reported around 1.335, and it requires careful storage, ideally at temperatures between 2-8°C, to maintain its stability and prevent degradation. These properties are crucial for ensuring the compound's reactivity and efficacy in subsequent synthetic steps.

The synthesis of (2R,3S)-3-Phenylisoserine is a sophisticated process that requires precise control over stereochemistry. Achieving the specific (2R,3S) configuration is a significant challenge in organic synthesis, often involving asymmetric synthesis techniques, chiral auxiliaries, or enzymatic resolution methods. The choice of synthetic route by a manufacturer is dictated by factors such as yield, purity, cost-effectiveness, and scalability. The starting materials and reaction conditions are carefully selected to minimize the formation of unwanted stereoisomers or impurities that could compromise the final product's suitability for pharmaceutical use.

The primary application driving the demand for (2R,3S)-3-Phenylisoserine is its role as a key precursor in the multi-step synthesis of Paclitaxel (Taxol). In this pathway, its chiral centers are critical for building the complex taxane ring system. The high purity requirement (typically ≥98% by NMR, as often specified) ensures that the chemical reactions proceed as intended, leading to the formation of the desired drug molecule with minimal byproducts. For researchers looking to buy this compound for similar complex syntheses, its well-defined chemical properties make it a reliable choice.

As a manufacturer, our focus is on optimizing these synthetic pathways to ensure consistent production of high-purity (2R,3S)-3-Phenylisoserine. This involves rigorous quality control at every stage, from raw material sourcing to final product testing. Understanding the chemistry of this intermediate allows us to provide products that meet the exacting standards of the pharmaceutical industry. We are dedicated to supplying CAS 136561-53-0 that enables critical pharmaceutical advancements.

In summary, the chemistry of (2R,3S)-3-Phenylisoserine, including its structure, physical properties, and synthesis, highlights its importance as a high-value pharmaceutical intermediate. Its specific chirality and purity are essential for its application in complex drug synthesis, such as Taxol. We are committed to providing researchers and manufacturers with this vital compound, backed by our expertise and dedication to quality.