The field of organic chemistry is rich with compounds that serve as fundamental pillars for scientific advancement. Among these, 4-Aminoquinaldine (CAS: 6628-04-2), also known scientifically as 4-Amino-2-methylquinoline or 2-Methylquinolin-4-amine, stands out due to its versatile chemical structure and broad utility, particularly as a pharmaceutical intermediate. Understanding its synthesis, properties, and applications is key for professionals in the chemical and pharmaceutical industries.

Synthesis Routes to 4-Aminoquinaldine

The production of 4-Aminoquinaldine involves established organic synthesis methodologies. Typically, its synthesis can be achieved through several routes, often involving the strategic manipulation of quinoline precursors. One common approach involves the reduction of 4-nitroquinaldine, where the nitro group is converted to an amine functionality. This reduction can be performed using various reducing agents, such as catalytic hydrogenation with palladium on carbon, or other chemical reducing systems. Another potential pathway might involve direct amination reactions of appropriately substituted quinoline derivatives under specific conditions. The choice of synthesis route often depends on factors like desired purity, yield, cost-effectiveness, and scalability for industrial production. For those looking to buy 4-aminoquinaldine manufacturer-direct, understanding their production capabilities and quality control measures is crucial.

Key Chemical and Physical Properties

4-Aminoquinaldine presents as a solid, typically a pale yellow to white powder. Its physical characteristics are well-defined: a melting point generally reported in the range of 162-166°C, and a boiling point of approximately 333°C. The compound exhibits moderate solubility in organic solvents like methanol. Its pKa value, around 9.40, indicates its basic nature, owing to the presence of the amino group. These properties make it suitable for a range of chemical transformations and formulations. When seeking a 4-amino-2-methylquinoline supplier price, these specifications are important indicators of product quality.

Diverse Applications of 4-Aminoquinaldine

The primary driver for the demand of 4-Aminoquinaldine is its extensive use as a pharmaceutical intermediate. It serves as a critical building block in the synthesis of various Active Pharmaceutical Ingredients (APIs). Research has highlighted its role in developing compounds with antileishmanial properties, essential for combating leishmaniasis, a neglected tropical disease. Furthermore, its derivatives have demonstrated significant antimicrobial activity, contributing to the ongoing search for new treatments against resistant pathogens.

Beyond medicinal chemistry, 4-Aminoquinaldine also garners interest in material science, where its unique structural attributes can be leveraged to create novel functional materials. This broad applicability underscores its value across research and industrial sectors. For organizations needing to source this compound, whether for research or large-scale manufacturing, understanding the options for CAS 6628-04-2 bulk purchase is beneficial.

As a reliable 2-methylquinolin-4-amine for sale provider, we are dedicated to ensuring the quality and availability of this vital chemical. If you are searching for 4-aminoquinaldine for sale, partnering with an experienced manufacturer is essential for securing consistent supply and product integrity.